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Titolo:
Is the distribution of dermal neurofibromas in neurofibromatosis type 1 (NF1) related to the pattern of the skin surface temperature?
Autore:
Kaufmann, D; Tinschert, S; Algermissen, B;
Indirizzi:
Univ Ulm, Abt Humangenet, D-89070 Ulm, Germany Univ Ulm Ulm Germany D-89070 v Ulm, Abt Humangenet, D-89070 Ulm, Germany Univ Klinikum Berlin, Charite, Inst Med Genet, D-10117 Berlin, Germany Univ Klinikum Berlin Berlin Germany D-10117 net, D-10117 Berlin, Germany Krankenhaus Neukolln, Abt Lasermed, D-12313 Berlin, Germany Krankenhaus Neukolln Berlin Germany D-12313 med, D-12313 Berlin, Germany
Titolo Testata:
EUROPEAN JOURNAL OF DERMATOLOGY
fascicolo: 6, volume: 11, anno: 2001,
pagine: 521 - 526
SICI:
1167-1122(200111/12)11:6<521:ITDODN>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT SEX DETERMINATION; BENIGN NEUROFIBROMAS; EXPRESSION; GENE; MELANOCYTES; MECHANISMS; TUMORS; MODEL;
Keywords:
neurofibromatosis type 1; neurofibroma; NFI; temperature; thermography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Kaufmann, D Univ Ulm, Abt Humangenet, Albert Einstein Allee 11, D-89070 Ulm, Germany Univ Ulm Albert Einstein Allee 11 Ulm Germany D-89070 Germany
Citazione:
D. Kaufmann et al., "Is the distribution of dermal neurofibromas in neurofibromatosis type 1 (NF1) related to the pattern of the skin surface temperature?", EUR J DERM, 11(6), 2001, pp. 521-526

Abstract

The formation of dermal neurofibromas is a hallmark of the neurofibromatosis type 1 (NF1). A total loss of the NF1 gene product by stochastic events inactivating the wild type allele in Schwann cells should precede the development of neurofibromas. Dermal neurofibromas tend to be located mainly on the surface of the trunk and not in the body periphery. This distribution partly resembles the density of sensitive nerve endings in the epidermis. Our hypothesis is that a better correlation concerns the pattern of normal body surface temperature. According to our clinical observations we assume that in skin areas with higher temperatures the number of visible dermal neurofibromas is higher than in colder areas such as the arms/legs or nose. It is known that differences in temperature are able to determine differentiation. We suggest that the regulation of skin temperature is also involved inthe formation of NF1 dermal neurofibromas and is related to the intrafamilial variability in NF1.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:09:06