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Titolo:
Collagen-receptor signaling in health and disease
Autore:
Vogel, WF;
Indirizzi:
Univ Frankfurt, Inst Biomed Res, Georg Speyer Haus, Lab Extracellular Matrix Signaling & Tumor Invas, D-60596 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-60596 vas, D-60596 Frankfurt, Germany
Titolo Testata:
EUROPEAN JOURNAL OF DERMATOLOGY
fascicolo: 6, volume: 11, anno: 2001,
pagine: 506 - 514
SICI:
1167-1122(200111/12)11:6<506:CSIHAD>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL ADHESION KINASE; NORMAL HUMAN KERATINOCYTES; SMOOTH-MUSCLE CELLS; TYROSINE KINASES; INTEGRIN ALPHA-2-BETA-1; IN-VIVO; CHROMOSOMAL LOCALIZATION; ALPHA-1-BETA-1 INTEGRIN; EXTRACELLULAR-MATRIX; GENE-EXPRESSION;
Keywords:
collagen; integrin; tyrosine kinase; discoidin domain receptor; matrix signaling; wound healing;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
119
Recensione:
Indirizzi per estratti:
Indirizzo: Vogel, WF Univ Frankfurt, Inst Biomed Res, Georg Speyer Haus, Lab Extracellular Matrix Signaling & Tumor Invas, D-60596 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-60596 96 Frankfurt, Germany
Citazione:
W.F. Vogel, "Collagen-receptor signaling in health and disease", EUR J DERM, 11(6), 2001, pp. 506-514

Abstract

Collagens are not only essential for the mechanical resistance and resilience of multicellular organisms, but are also signaling molecules defining cellular shape and behavior. The communication between collagens and cells is achieved by cell surface receptors. Three types of cell surface receptorsfor collagen are known: integrins, discoidin domain receptors and glycoprotein VI. All three types independently trigger a variety of signaling pathways upon collagen-binding. Besides regulating numerous cellular responses, both integrin and discoidin domain receptors monitor the integrity of the collagenous extracellular matrix by triggering matrix degradation and renewal. Some recently discovered mechanisms of locally controlled expression of collagen, collagen-binding receptors and collagen-degrading proteases in the cellular microenvironment are described.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/06/20 alle ore 23:55:59