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Titolo:
Off-pump versus on-pump coronary artery bypass grafting: oxidative stress and renal function
Autore:
Gerritsen, WBM; van Boven, WJP; Driessen, AHG; Haas, FJLM; Aarts, LPHJ;
Indirizzi:
St Antonius Hosp, Dept Clin Chem, Nieuwegein, Netherlands St Antonius Hosp Nieuwegein Netherlands n Chem, Nieuwegein, Netherlands St Antonius Hosp, Dept Cardiothorac Surg, Nieuwegein, Netherlands St Antonius Hosp Nieuwegein Netherlands c Surg, Nieuwegein, Netherlands St Antonius Hosp, Dept Anesthesiol, Nieuwegein, Netherlands St Antonius Hosp Nieuwegein Netherlands hesiol, Nieuwegein, Netherlands
Titolo Testata:
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
fascicolo: 5, volume: 20, anno: 2001,
pagine: 923 - 929
SICI:
1010-7940(200111)20:5<923:OVOCAB>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOPULMONARY BYPASS; MALONDIALDEHYDE; CIRCULATION; PERFUSION;
Keywords:
oxidative stress; ischemia/reperfusion injury; cardiopulmonary bypass; purities; malondialdehyde; renal function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Gerritsen, WBM St Antonius Hosp, Dept Clin Chem, Nieuwegein, Netherlands St Antonius Hosp Nieuwegein Netherlands ein, Netherlands
Citazione:
W.B.M. Gerritsen et al., "Off-pump versus on-pump coronary artery bypass grafting: oxidative stress and renal function", EUR J CAR-T, 20(5), 2001, pp. 923-929

Abstract

Objectives: Oxidative stress and renal dysfunction occur in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass (on-pump CABG). Whether the same adverse effects also occur during off-pump CABG is the question in this study. Methods: Forty patients, 27 men and 13 women, undergoing elective CABG were included; 20 patients underwent on-pump CABG and 20 patients underwent off-pump CABG. Renal and ischemia/reperfusion injury parameters were studied, as well as malondialdehyde as a parameter for oxidative stress. Results: The renal function measured as the mean urinary creatinine excretion decreased significantly during surgery for the on-pump CABG group from 7.62 +/- 4.74 before surgery to 3.07 +/- 1.49 mmol/l after surgery, whereas no changes occurred in the off-pump CABG group. The mean urinary concentrations of hypoxanthine, xanthine and malondialdehyde expressed as creatinine ratios for the on-pump group increased significantly from 1.92 +/- 1.36, 6.06 +/- 3.62 and 0.21 +/- 0.07 before surgery to 11.88 +/- 5.77, 13.11 +/- 6.61 and 0.57 +/- 0.31 mmol/mol creatinine, respectively atarrival to the intensive care unit (ICU). During the next time-points, thepurities and malondialdehyde decreased to 9.21 +/- 7.46, 7.55 +/- 3.95 and0.32 +/- 0.13 mmol/mol creatinine, respectively after a 20 h stay at the ICU. For the off-pump CABG group, the mean ratios also increased significantly from 1.71 +/- 1.38, 2.01 +/- 0.96 and 0.16 +/- 0.10 before surgery to 4.73 +/- 3.19, 5.15 +/- 3.74 and 0.23 +/- 0.17 mmol/mol creatinine, respectively at arrival to the ICU. During the next time-points, the ratios of xanthine and malondialdehyde decreased to 3.80 +/- 2.92 and 0.24 +/- 0.13 mmol/mol creatinine, respectively. The ratio for hypoxanthine reached the highestratio (6.97 +/- 5.67 mmol/mol creatinine) after a 9 h stay at the ICU, after which the ratio decreased to 5.98 +/- 5.56 mmol/ mod creatinine after a 20 h stay at the ICU. However, all ratios from the on- and off-pump CABG patients still remained elevated compared with preoperative ratios. In addition, all ratios for the on-pump CABG group were elevated significantly at all time-points for xanthine, at time-points T2 and T4 for hypoxanthine and at time-point T2 for malondialdehyde as compared with the off-pump CABG group. Conclusions: Only mild signs of oxidative stress and no renal dysfunction were found during and after off-pump CABG compared with on-pump CABG. (C)2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 14:15:30