Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The electrophysiological basis for the antiarrhythmic actions of polyunsaturated fatty acids
Autore:
Leaf, A;
Indirizzi:
Massachusetts Gen Hosp, Dept Med, Charlestown, MA 02129 USA Massachusetts Gen Hosp Charlestown MA USA 02129 Charlestown, MA 02129 USA Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA Harvard Univ BostonMA USA 02115 Sch Med, Dept Med, Boston, MA 02115 USA
Titolo Testata:
EUROPEAN HEART JOURNAL SUPPLEMENTS
fascicolo: D, volume: 3, anno: 2001,
pagine: D98 - D105
SICI:
1520-765X(200106)3:D<D98:TEBFTA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT CARDIAC MYOCYTES; VENTRICULAR MYOCYTES; ALPHA-SUBUNIT; NA+ CHANNELS; LONG-CHAIN; CLASS-I; PREVENTION; ARRHYTHMIAS; CURRENTS; SODIUM;
Keywords:
omega-3; n-3; omega-6; n-6; eicosapentaenoic acid; docosahexaenoic acid; arrhythmias; seizures;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Leaf, A Massachusetts Gen Hosp, Dept Med, E Bldg 149,13th St, Charlestown,MA 02129 USA Massachusetts Gen Hosp E Bldg 149,13th St Charlestown MA USA 02129
Citazione:
A. Leaf, "The electrophysiological basis for the antiarrhythmic actions of polyunsaturated fatty acids", EUR H J SUP, 3(D), 2001, pp. D98-D105

Abstract

Aims To determine whether n-3 polyunsaturated fatty acids (PUFAs) have cardiac antiarrhythmic effects. and, if so, to determine the basis(es) for such an effect. Methods and results First, tests were made of the ability of administeringn-3 PUFAs to a reliable dog model to prevent ischaemia-induced sudden cardiac death. Infusion of an emulsion of fish oil free fatty acids just prior to coronary artery obstruction prevented ventricular fibrillation (VF) (P <0.005) in exercising, unanaesthetized dogs. Similar results were obtained with pure n-3 free docosahexaenoic, eicosapentaenoic or alpha-linolenic acids. PUFAs prevented induced fibrillation of cultured neonatal rat cardiomyocytes for all cardiotoxins tested. After fibrillation was induced, the arrhythmias were terminated by the PUFAs. The electrophysiological effects of low micromolar concentrations of PUFAs are to increase the depolarizing currentrequired to elicit an action potential by about 50% and prolong the refractory period by about threefold. These effects result because the PUFAs, modulate the conductance of ion channels, primarily of Na+ and Ca2+, in cardiomyocytes from neonatal and adult rats, and the human myocardial Na+ channelwith the alpha-subunit and the alpha+beta-subunits transiently expressed in HEK293t cells using whole cell patch-clamp. Conclusions These dietary PUFAs are shown to be potent, safe antiarrhythmic agents. More clinical trials, such as the GISSI-Prevenzione, are needed to extend these findings to humans. Potential, very large public health benefits may accrue from this new understanding. (C) 2001 The European Society of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 08:44:21