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Titolo:
Dietary omega-3 fatty acids and human growth factor and cytokine gene expression
Autore:
von Schacky, C;
Indirizzi:
Univ Munich, Med Klin Innenstadt, D-8000 Munich, Germany Univ Munich Munich Germany D-8000 lin Innenstadt, D-8000 Munich, Germany
Titolo Testata:
EUROPEAN HEART JOURNAL SUPPLEMENTS
fascicolo: D, volume: 3, anno: 2001,
pagine: D50 - D52
SICI:
1520-765X(200106)3:D<D50:DOFAAH>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN MONONUCLEAR-CELLS; FACTOR MESSENGER-RNA; CONTROLLED TRIAL; CORONARY ATHEROSCLEROSIS; INFLAMMATORY DISEASE; DOUBLE-BLIND; FISH-OIL; OMEGA-3-FATTY-ACIDS; REGRESSION; DEATH;
Keywords:
atherosclerosis; coronary artery disease; secondary prevention; mononuclear cells; volunteer study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: von Schacky, C Klinikum Univ Munchen, Med Klin, Standort Innenstadt, Ziemssenstr 1, D-80336 Munich, Germany Klinikum Univ Munchen Ziemssenstr 1 Munich Germany D-80336
Citazione:
C. von Schacky, "Dietary omega-3 fatty acids and human growth factor and cytokine gene expression", EUR H J SUP, 3(D), 2001, pp. D50-D52

Abstract

The pathogenesis of atherosclerosis has an inflammatory component that is deemed to play an important role in the development of alterations in the vessel wall, ultimately resulting in plaques and other abnormalities that narrow the artery's lumen. The extent and the speed of development of this inflammatory component is currently thought to be largely, modulated by cytokines. and growth factors. Among all classes of dietary unsaturated fatty acids studied so far, only omega-3 fatty acids down-regulate ex vivo expression of PDGF-A, PDGF-B, and MCP-1 in mononuclear cells. This down-regulation persists despite stimulation/differentiation of these cells, by adherence. The down-regulation is specific and selective for PDGF-A,, PDGF-B and MCP-1, which are thought to promote atherogenesis. This was found to be reflected in a reduced progression/increased regression of coronary lesions in a coronary angiography study, lending support to the importance of PDGF-A, PDGF-B and MCP-1 in the pathogenesis of atherosclerosis. (C) 2001 The European Society of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:36:36