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Titolo:
n-3 fatty acids and the inflammatory response - biological background
Autore:
De Caterina, R; Basta, G;
Indirizzi:
CNR, Inst Clin Physiol, Lab Thrombosis & Vasc Res, I-56100 Pisa, Italy CNR Pisa Italy I-56100 l, Lab Thrombosis & Vasc Res, I-56100 Pisa, Italy G dAnnunzio Univ, Chair Cardiol, Chieti, Italy G dAnnunzio Univ Chieti Italy nunzio Univ, Chair Cardiol, Chieti, Italy
Titolo Testata:
EUROPEAN HEART JOURNAL SUPPLEMENTS
fascicolo: D, volume: 3, anno: 2001,
pagine: D42 - D49
SICI:
1520-765X(200106)3:D<D42:NFAATI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC GLOMERULAR-DISEASE; MEMBRANE LIPID-COMPOSITION; COD LIVER OIL; FISH-OIL; EICOSAPENTAENOIC ACID; DIETARY SUPPLEMENTATION; PLATELET-FUNCTION; DOCOSAHEXAENOIC ACIDS; THROMBOXANE SYNTHESIS; GREENLAND ESKIMOS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: De Caterina, R CNR, Inst Clin Physiol, Lab Thrombosis & Vasc Res, Via Moruzzi 8, I-56100 Pisa, Italy CNR Via Moruzzi 8 Pisa Italy I-56100 , I-56100 Pisa, Italy
Citazione:
R. De Caterina e G. Basta, "n-3 fatty acids and the inflammatory response - biological background", EUR H J SUP, 3(D), 2001, pp. D42-D49

Abstract

Inflammation can be defined as the reaction of a living vascularized tissue to a localized damage, and plays a role in both normal repair reactions and in the pathogenesis, of disease. Inflammatory phenomena are at the basisof a number of disease processes in virtually any systemic or organ-specific disease, ranging from classical rheumatic diseases to bronchial airway hyper-responsiveness, inflammatory bowel disease, kidney diseases, psoriasisand atopic eczema. Modulation of long-chain polyunsaturated fatty acid intake, mostly by increasing the relative proportions of n-3 versus n-6 fatty acids, is the clearest example of how diet may modulate the inflammatory process. It is possible that many of the environmentally attributable epidemiological differences in the incidence of inflammatory diseases among different populations can be tracked back to different nutritional intake of selected, quantitatively minor nutritional components such as omega-3 fatty acids. The increase in dietary intake of these compounds, or their pharmacological supplementation, leads to a moderate quenching of the inflammatory reaction which may prove useful in selected clinical conditions. The clarification of the mechanisms of the biological action of these, as well as of other dietary components, and a better documentation of the spectrum of clinical possibilities offered by dietary manipulation in the intake of such compound's, linking together classical nutritional science, molecular biology, epidemiology and clinical medicine, are a frontier for nutritional researchin the years to come. This nutritional approach promises to gain a place in the therapy of some inflammatory disorders. (C) 2001 The European Societyof Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 02:08:34