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Titolo:
Changes in cardiac metabolism: a critical step from stable angina to ischaemic cardiomyopathy
Autore:
Stanley, WC;
Indirizzi:
Case Western Reserve Univ, Sch Med, Dept Physiol & Biophys, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA
Titolo Testata:
EUROPEAN HEART JOURNAL SUPPLEMENTS
fascicolo: O, volume: 3, anno: 2001,
pagine: O2 - O7
SICI:
1520-765X(200111)3:O<O2:CICMAC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
FATTY-ACID OXIDATION; MYOCARDIAL-METABOLISM; GLUCOSE-METABOLISM; MAMMALIAN HEART; NICOTINIC-ACID; ISCHEMIA; CARBOHYDRATE; HUMANS; TRIMETAZIDINE; INHIBITION;
Keywords:
angina pectoris; cardiac; coronary artery disease; fatty acids; glucose; heart; lactate; metabolism; mitochondria;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Stanley, WC Case Western Reserve Univ, Sch Med, Dept Physiol & Biophys, 10900 Euclid Ave, Cleveland, OH 44106 USA Case Western Reserve Univ 10900 Euclid Ave Cleveland OH USA 44106
Citazione:
W.C. Stanley, "Changes in cardiac metabolism: a critical step from stable angina to ischaemic cardiomyopathy", EUR H J SUP, 3(O), 2001, pp. O2-O7

Abstract

Cardiac work requires a high rate of adenosine triphosphate (ATP) breakdown. ATP is resynthesized in the mitochondria with energy from the combustionof fatty acids, glucose and lactate. Fatty acids are the main fuel for theheart, supplying 60-90% of the energy, with the balance (10-40%) from pyruvate oxidation (formed from glycolysis and lactate). Fatty acid oxidation inhibits pyruvate oxidation in the mitochondria. During myocardial ischaemia, oxygen consumption and ATP production is reduced, causing accelerated glycolysis and lactate production; the pH falls and cell function is impaired. Paradoxically, with a partial reduction in coronary flow, the myocardium continues to derive most of its energy from the oxidation of fatty acids despite a high rate of lactate productions this fatty acid oxidation during ischaemia inhibits pyruvate oxidation, and drives pyruvate conversion to lactate. Partial inhibition of fatty acid oxidation in ischaemic myocardium. such as with the long-chain 3-ketoacyl thiolase inhibitor trimetazidine, reduces lactate production and H+ accumulation during ischaemia. and results inclinical benefit in patients with angina pectoris. (C) 2001 The European Society of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 06:33:37