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Titolo:
Bioanalytical screening methods for dioxins and dioxin-like compounds - a review of bioassay/biomarker technology
Autore:
Behnisch, PA; Hosoe, K; Sakai, S;
Indirizzi:
Kaneka Corp, Life Sci Res Labs, Takasago, Hyogo, Japan Kaneka Corp Takasago Hyogo Japan fe Sci Res Labs, Takasago, Hyogo, Japan
Titolo Testata:
ENVIRONMENT INTERNATIONAL
fascicolo: 5, volume: 27, anno: 2001,
pagine: 413 - 439
SICI:
0160-4120(200111)27:5<413:BSMFDA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ETHOXYRESORUFIN-O-DEETHYLASE; ARYL-HYDROCARBON HYDROXYLASE; DIBENZO-P-DIOXINS; POLYCYCLIC AROMATIC-HYDROCARBONS; POLYCHLORINATED-BIPHENYLS PCBS; TOXIC EQUIVALENCY FACTORS; HEPATOMA-CELL BIOASSAY; DETERMINING 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN EQUIVALENTS; RESPONSIVE TRANSCRIPTIONAL ENHANCER; PLANAR HALOGENATED HYDROCARBONS;
Keywords:
dioxin; dioxin-like compounds; bioassay; biomarker; biomonitoring; dioxin toxic equivalents quotient (TEQ); polychlorinated biphenyls (PCBs); polychlorinated dibenzodioxins (PCDD); polychlorinated dibenzofurans (PCDF);
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
243
Recensione:
Indirizzi per estratti:
Indirizzo: Behnisch, PA Kaneka Corp, Life Sci Res Labs, Takasago, Hyogo, Japan KanekaCorp Takasago Hyogo Japan bs, Takasago, Hyogo, Japan
Citazione:
P.A. Behnisch et al., "Bioanalytical screening methods for dioxins and dioxin-like compounds - a review of bioassay/biomarker technology", ENVIRON INT, 27(5), 2001, pp. 413-439

Abstract

Determination of environmental pollutants utilizing biodetectors such as bioassays, biomarkers, enzyme immunoassays (EIAs), or other bioanalytical tools is a continuously growing area. The present literature review describesthe principles and advantages/limitations of several bioanalytical detection methods (BDMs) for the screening and diagnosis of dioxin and dioxin-likecompounds. This study characterizes briefly the family of dioxin and dioxin-like compounds, discusses potential Ah receptor (AhR) ligands and cytochrome P-450 (CYP) 1A1-enzyme-inducing compounds. 'Milestones' in the development of BDMs are summarized and explained in detail for a number of bioanalytical tools that can be used to detect these classes of dioxin-like persistent bioaccumulative toxicants (PBTs). The design of a screening profile with a battery of bioassays/biomarkers coupled with the chemical analysis is evaluated. The relative potencies (REPs) to 2,3,7,8-TCDD for dioxin-like compounds are reviewed for various BDMs and the differences are noted. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 12:24:40