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Titolo:
BISARAMIL AND ANTIARRHYTHMICS AS INHIBITORS OF FREE-RADICAL GENERATION
Autore:
PAROCZAI M; ROTH E; KARPATI E;
Indirizzi:
CHEM WORKS GEDEON RICHTER LTD,PHARMACOL RES CTR,POB 27 H-1475 BUDAPEST 10 HUNGARY UNIV PECS,SCH MED,INST EXPT SURG PECS HUNGARY
Titolo Testata:
Pharmacological research
fascicolo: 4, volume: 35, anno: 1997,
pagine: 279 - 285
SICI:
1043-6618(1997)35:4<279:BAAAIO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL INFARCT SIZE; REPERFUSION-INDUCED ARRHYTHMIAS; CORONARY-ARTERY REPERFUSION; NEUTROPHIL DEPLETION; INJURY; LEUKOCYTES; ISCHEMIA; REDUCTION; OCCLUSION; PROTECTION;
Keywords:
FREE RADICALS; POLYMORPH NEUTROPHIL GRANULOCYTES; BISARAMIL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
M. Paroczai et al., "BISARAMIL AND ANTIARRHYTHMICS AS INHIBITORS OF FREE-RADICAL GENERATION", Pharmacological research, 35(4), 1997, pp. 279-285

Abstract

The aim of this study was to investigate the effect of bisaramil-an antiarrhythmic drug under clinical trials-on free radical generation ofisolated polymorph neutrophil granulocytes (PMN) and furthermore to compare its activity to that of well-known antiarrhythmics which have different modes of action, PMNs were isolated from healthy beagle dogs,and superoxide radical generation was induced by phorbol-myristate-acetate. Stimulated free radical generation capacity of PMNs and the time lag necessary for the initiation of free radical production were measured. All Compounds were used at the concentrations of 10, 25, 50, 75, 100 mu g ml(-1). None of the antiarrhythmics stimulated by itself the free radical generation. Bisaramil exerted concentration dependent inhibitory effect on PMA-stimulated free radical generation and prolonged the time lag concentration dependently. At the investigated concentration range of antiarrhythmics only propafenon, mexiletine and diltiazem showed similar activity to bisaramil, but clear concentration dependency could not be seen in any of the cases. According to the resultsof this study inhibition of the stimulated free radical production ofisolated PMNs cannot be closely connected merely to either membrane stabilizing or Ca-antagonistic activity of drugs. In vitro and earlier measured in vivo inhibitory action of bisaramil on free radical generation indicate a possible cardioprotective effect existing independently from its antiarrhythmic one. This observation may be important in outlining of the clinical indication field of bisaramil, and may be useful in the treatment of reperfusional damage. (C) 1997 The Italian Pharmacological Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 03:41:33