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Titolo:
Basal and fat-stimulated plasma peptide YY levels in celiac disease
Autore:
Wahab, PJ; Hopman, WPM; Jansen, JBMJ;
Indirizzi:
Univ Nijmegen Hosp, Dept Gastroenterol & Hepatol, NL-6500 HB Nijmegen, Netherlands Univ Nijmegen Hosp Nijmegen Netherlands NL-6500 HB Nijmegen, Netherlands
Titolo Testata:
DIGESTIVE DISEASES AND SCIENCES
fascicolo: 11, volume: 46, anno: 2001,
pagine: 2504 - 2509
SICI:
0163-2116(200111)46:11<2504:BAFPPY>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PANCREATIC EXOCRINE SECRETION; GASTRIC-ACID SECRETION; ENDOCRINE-CELLS; GUT HORMONE; RELEASE; PYY; CHOLECYSTOKININ; INHIBITION; TRANSIT; RADIOIMMUNOASSAY;
Keywords:
celiac disease; peptide YY; cholecystokinin; lipid digestion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Hopman, WPM Univ Nijmegen Hosp, Dept Gastroenterol & Hepatol, POB 9101, NL-6500 HB Nijmegen, Netherlands Univ Nijmegen Hosp POB 9101 Nijmegen Netherlands NL-6500 HB s
Citazione:
P.J. Wahab et al., "Basal and fat-stimulated plasma peptide YY levels in celiac disease", DIG DIS SCI, 46(11), 2001, pp. 2504-2509

Abstract

The distal gut hormone peptide YY (PYY) mediates feedback inhibition of gastric acid secretion, gastrointestinal motility, and pancreatic enzyme output. To investigate; the influence of maldigestion on PYY, we determined plasma PYY levels in patients with celiac disease under basal conditions and in response to intraduodenal fat. Basal PYY was increased in untreated celiac patients (N = 13) compared to patients on a gluten free diet (N = 9) [15.6 (11.8-27.0) pM vs 12.2 (10.1-13.1) pM; P < 0.05] and compared to control subjects (N = 15) [9.5 (8.3-10.4) pM; P < 0.001]. Integrated PYY in response to intraduodenally infused predigested fat (1071 +/- 293 pM 80 min) was significantly (P < 0.05) greater than in response to undigested fat (322 <plus/minus> 223 pM 80 min) in six untreated celiacs. Plasma concentrations ofPYY and cholecystokinin were strongly correlated (r = 0.79; P < 0.001). Weconclude that basal PYY levels in untreated celiac disease are elevated, that predigestion of fat enhances PYY release in these patients, and that PYY secretion is correlated with CCK release.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:17:30