Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Hepatitis C virus (HCV) RNA determination after two weeks of induction interferon treatment is an accurate predictor of nonresponse - Comparison of two treatment schedules
Autore:
Rossini, A; Artini, M; Levrero, M; Almerighi, C; Massari, M; Biasi, L; Radaeli, E; Cariani, E;
Indirizzi:
AO Spedali Civili, Dept Internal Med 3, Hepatol Unit, I-25123 Brescia, Italy AO Spedali Civili Brescia Italy I-25123 tol Unit, I-25123 Brescia, Italy Univ Roma La Sapienza, Fdn A Cesalpino, Rome, Italy Univ Roma La SapienzaRome Italy Sapienza, Fdn A Cesalpino, Rome, Italy Univ Cagliari, Dept Internal Med, I-09124 Cagliari, Italy Univ Cagliari Cagliari Italy I-09124 ternal Med, I-09124 Cagliari, Italy Hosp S Maria Nuova, Dept Infect Dis, Reggio Emilia, Italy Hosp S Maria Nuova Reggio Emilia Italy Infect Dis, Reggio Emilia, Italy AO Spedali Civili, Lab 3, Brescia, Italy AO Spedali Civili Brescia Italy O Spedali Civili, Lab 3, Brescia, Italy
Titolo Testata:
DIGESTIVE DISEASES AND SCIENCES
fascicolo: 11, volume: 46, anno: 2001,
pagine: 2389 - 2395
SICI:
0163-2116(200111)46:11<2389:HCV(RD>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
DYNAMICS IN-VIVO; RIBAVIRIN; THERAPY; ALPHA; COMBINATION; QUANTIFICATION; TURNOVER; ALFA;
Keywords:
viral kinetics; interferon; induction therapy; predictive factors; HCV genotypes; HCV viral load;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Rossini, A AO Spedali Civili, Dept Internal Med 3, Hepatol Unit, P SpedaliCivili 1, I-25123 Brescia, Italy AO Spedali Civili P Spedali Civili 1 Brescia Italy I-25123 aly
Citazione:
A. Rossini et al., "Hepatitis C virus (HCV) RNA determination after two weeks of induction interferon treatment is an accurate predictor of nonresponse - Comparison of two treatment schedules", DIG DIS SCI, 46(11), 2001, pp. 2389-2395

Abstract

The aim of this study was to analyze of HCV kinetics during interferon treatment administered daily or three times weekly. Seventy-seven naive patients were randomized to two treatment courses starting with four weeks of high-dose interferon administered daily or three times weekly. Twenty-two patients (28.6%) achieved end-of-treatment response and nine (11.7%, four of whom received daily induction) sustained response. The initial decline of viral load was sharper in patients receiving daily induction, but the rates ofearly RNA clearance were independent of treatment schedule, being higher in patients with genotype non-1. Detectable HCV RNA during treatment predicted nonresponse more significantly than high pretreatment viral load or genotype 1. HCV RNA at week 2 was the best predictor (100% sensitivity in patients receiving daily induction). In conclusion, daily induction increased the HCV decline slope, but not the rate of virological response. HCV RNA at week 2 reliably identified nonresponders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:24:36