Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Changes of colonic mucosal microcirculation and histology in two colitis models - An experimental study using intravital microscopy and a new histological scoring system
Autore:
Kruschewski, M; Foitzik, T; Perez-Canto, A; Hubotter, A; Buhr, HJ;
Indirizzi:
Free Univ Berlin, Univ Med Ctr Benjamin Franklin, Dept Surg, D-12200 Berlin, Germany Free Univ Berlin Berlin Germany D-12200 pt Surg, D-12200 Berlin, Germany Free Univ Berlin, Univ Med Ctr Benjamin Franklin, Dept Pathol, D-12200 Berlin, Germany Free Univ Berlin Berlin Germany D-12200 Pathol, D-12200 Berlin, Germany
Titolo Testata:
DIGESTIVE DISEASES AND SCIENCES
fascicolo: 11, volume: 46, anno: 2001,
pagine: 2336 - 2343
SICI:
0163-2116(200111)46:11<2336:COCMMA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY BOWEL-DISEASE; ULCERATIVE-COLITIS; CROHNS-DISEASE; BLOOD-FLOW; RAT COLON; HEMODYNAMICS; ARCHITECTURE; IMPAIRMENT; ACID;
Keywords:
microcirculation; intravital microscopy; histological scoring system; TNBS colitis; mitomycin colitis; inflammatory bowel disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Kruschewski, M Free Univ Berlin, Univ Med Ctr Benjamin Franklin, Dept Surg, Hindenburgdamm 30, D-12200 Berlin, Germany Free Univ Berlin Hindenburgdamm 30 Berlin Germany D-12200
Citazione:
M. Kruschewski et al., "Changes of colonic mucosal microcirculation and histology in two colitis models - An experimental study using intravital microscopy and a new histological scoring system", DIG DIS SCI, 46(11), 2001, pp. 2336-2343

Abstract

This study investigated capillary blood flow (CBF) and pathomorphological alterations in the mucosa of different bowel segments at different times after disease onset in rats with colitis induced by either trinitrobenzensulfonic acid (TNBS) or mitomycin-C. CBF was determined by intravital microscopy using fluorescein-labeled erythrocytes. The histological degree of inflammation was assessed by a new scoring system. Severe acute histological changes were found in the distal colon 24 hr after induction of TNBS colitis (score: 8.9 +/- 1.0). CBF was increased (2.9 +/- 0.05 vs. 2.6 +/- 0.04 nl/minin healthy controls). The histological alterations persisted until day 3 (8.5 +/- 0.9) when CBF significantly decreased (1.8 +/- 0.05 nl/min). After 15 days, moderate acute inflammation was still detectable histologically (5.4 +/- 1.3), but CBF had returned to normal values. In mitomycin-C colitis,changes developed mainly in the proximal colon: After three days, there was mild inflammation (2.8 +/- 1.2) with normal CBF (2.5 +/- 0.1 nl/min). After seven days, the inflammation had increased (4.8 +/- 1.1), while CBF had decreased (1.5 +/- 0.06 nl/min). These changes persisted for six weeks (5.3+/- 0.7; 1.2 +/- 0.05 nl/min). These data suggest that disturbed colonic microcirculation may play an important role in the pathogenesis of inflammatory bowel disease regardless of the histopathomorphological alterations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:50:38