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Titolo:
Common origins of blood and blood vessels in adults?
Autore:
Hirschi, KK; Goodell, MA;
Indirizzi:
Baylor Coll Med, Ctr Cell & Gene Therapy, Dept Pediat, Childrens Nutr Res Ctr, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 Nutr Res Ctr, Houston, TX 77030 USA Baylor Coll Med, Ctr Cell & Gene Therapy, Dept Mol & Cellular Biol, Childrens Nutr Res Ctr, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 Nutr Res Ctr, Houston, TX 77030 USA Baylor Coll Med, Ctr Cell & Gene Therapy, Dept Immunol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 Dept Immunol, Houston, TX 77030 USA Baylor Coll Med, Ctr Cell & Gene Therapy, Dept Human & Mol Genet, Houston,TX 77030 USA Baylor Coll Med Houston TX USA 77030 an & Mol Genet, Houston,TX 77030 USA
Titolo Testata:
DIFFERENTIATION
fascicolo: 4-5, volume: 68, anno: 2001,
pagine: 186 - 192
SICI:
0301-4681(200110)68:4-5<186:COOBAB>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMATOPOIETIC STEM-CELLS; ENDOTHELIAL PROGENITOR CELLS; POSTNATAL NEOVASCULARIZATION; BONE-MARROW; IN-VIVO; VEGF; GROWTH; ANGIOGENESIS; MOUSE; MICE;
Keywords:
adult stem cells; hematopoiesis; blood vessel;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Hirschi, KK Baylor Coll Med, Ctr Cell & Gene Therapy, Dept Pediat, Childrens Nutr Res Ctr, 1 Baylor Plaza, Houston, TX 77030 USA Baylor Coll Med 1 Baylor Plaza Houston TX USA 77030 77030 USA
Citazione:
K.K. Hirschi e M.A. Goodell, "Common origins of blood and blood vessels in adults?", DIFFERENTIA, 68(4-5), 2001, pp. 186-192

Abstract

After embryonic development, the vast majority of cells are differentiatedand all organs are in place. Growth of the organism then ensues and continues until adulthood, whereupon cell division largely ceases. In some tissues, notably the bone marrow, skin, and gut, cell proliferation continues throughout life to replace cells lost by attrition. This regeneration is fueled by rare, long-lived, and largely quiescent stem cells that give rise to committed progenitors, which in turn generate large numbers of fully differentiated cells. Mounting evidence suggests that such cells can significantlycontribute to tissue repair and regeneration in adults and may therefore prove beneficial for autologous cell and gene therapies. This review focuseson the potential of adult stem cells to give rise to hematopoietic and vascular cells. We discuss evidence that a highly purified population of adultstem cells, termed SP cells, serves as a hematopoietic progenitor and can contribute to vascular regeneration after injury. We also discuss the potential relationship of these cells to the embryonic hemangioblast.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 13:35:20