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Titolo:
Advanced glycation end products, their receptors and diabetic angiopathy
Autore:
Wautier, JL; Guillausseau, PJ;
Indirizzi:
Univ Paris 07, Inst Natl Transfus Sanguine, UFR Labroisiere St Louis, Lab Biol Vasc & Cellulaire, F-75739 Paris 15, France Univ Paris 07 Paris France 15 asc & Cellulaire, F-75739 Paris 15, France Hop Lariboisiere, Serv Med B, F-75010 Paris, France Hop Lariboisiere Paris France F-75010 Serv Med B, F-75010 Paris, France
Titolo Testata:
DIABETES & METABOLISM
fascicolo: 5, volume: 27, anno: 2001,
parte:, 1
pagine: 535 - 542
SICI:
1262-3636(200111)27:5<535:AGEPTR>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINAL CAPILLARY PERICYTES; ENDOTHELIAL GROWTH-FACTOR; ADVANCED GLYCOSYLATION; VASCULAR DYSFUNCTION; AMINOGUANIDINE TREATMENT; LIPID-PEROXIDATION; MAILLARD REACTION; SOLUBLE RECEPTOR; GENE-EXPRESSION; OXIDANT STRESS;
Keywords:
diabetic angiopathy; hyperglycemia; advanced glycation end-products; receptor for advanced glycation end-products (RAGE); glycoxidation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Wautier, JL Univ Paris 07, Inst Natl Transfus Sanguine, UFR Labroisiere StLouis, Lab Biol Vasc & Cellulaire, 6 Rue Alexandre Cabanel, F-75739 Paris 15, France Univ Paris 07 6 Rue Alexandre Cabanel Paris France 15 France
Citazione:
J.L. Wautier e P.J. Guillausseau, "Advanced glycation end products, their receptors and diabetic angiopathy", DIABETE MET, 27(5), 2001, pp. 535-542

Abstract

The role of chronic hyperglycemia in the development of diabetic microvascular complications and in neuropathy has been clearly established by intervention studies. However, the biochemical or cellular links between elevatedblood glucose levels, and the vascular lesions remain incompletely understood. This review focuses on the consequences of hyperglycemia on the formation of advanced glycation end-products (AGEs), and on the role of AGEs and of their specific receptors (RAGE) in the functional and anatomical alterations of the vascular wall. AGEs are formed during the Mailiard reaction by the binding of aldoses on free NH2 groups of proteins, which, after a cascade of molecular rearrangements, result in molecules of brown color and specific fluorescence. Experimental studies have indicated that the binding of AGEs to RAGE activates cells, particularly monocytes and endothelial calls. Activated endothelial cells produce cytokines, and express adhesion molecules and tissue factor. The role of AGEs in increased oxidative stress, and in the functional alterations in vascular tone control observed in diabetes, in part related to a reduction in nitric oxide, is also discussed. The microvascular retinal, glomerular and nerve lesions induced by experimental diabetes in animals are prevented by an inhibitor of AGEs formation, aminoguanidine. The administration in diabetic animals of recombinant RAGE, which hinders AGEs-RAGE interaction, prevents hyperpermeability and vascular lesions. These data suggest a central role of AGEs and RAGE in the development of chronic complications of diabetes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:26:44