Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Insulin and weight gain in type 2 diabetic patients : myth or reality ?
Autore:
Larger, E; Rufat, P; Dubois-Laforgue, D; Ledoux, S;
Indirizzi:
Hop Bichat, Serv Diabetol Endocrinol, F-75877 Paris 18, France Hop BichatParis France 18 Diabetol Endocrinol, F-75877 Paris 18, France
Titolo Testata:
DIABETES & METABOLISM
fascicolo: 5, volume: 27, anno: 2001,
parte:, 3
pagine: S23 - S27
SICI:
1262-3636(200111)27:5<S23:IAWGIT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
FRE
Soggetto:
GLYCEMIC CONTROL; RISK-FACTORS; BODY-WEIGHT; SECONDARY-FAILURE; FOLLOW-UP; MELLITUS; THERAPY; OBESITY; COMPLICATIONS; SULFONYLUREA;
Keywords:
type 2 diabetes; insulin; weight gain; obesity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Larger, E Hop Bichat, Serv Diabetol Endocrinol, 46 Rue H Huchard, F-75877 Paris 18, France Hop Bichat 46 Rue H Huchard Paris France 18 77 Paris 18, France
Citazione:
E. Larger et al., "Insulin and weight gain in type 2 diabetic patients : myth or reality ?", DIABETE MET, 27(5), 2001, pp. S23-S27

Abstract

Most patients with type 2 diabetes gain weight when treated with insulin, Weight gain is observed when insulin is introduced after oral agents have failed, but also when insulin is introduced shortly after the diagnosis of diabetes. The mechanisms of this weight gain are uncompletely understood, but reduction of energy lost by glucosuria and reduction of energy needed forglucose production are main determinants. The same reasons apply to the weight gain observed at the beginning of treatment with sulfonylureas, even though patients usually gain less weight with sulfonyulreas than with Insulin. In the UKPDS, at 10 years of the study, patients treated with insulin gained 2 kg more, i. e. 2.5% of the average weight of patients included in the trial, than patients treated with suffonylureas. The reasons of the excess of weight gain with insulin as compared with sulfonylureas remain unclear. Patients with type 2 diabetes treated with insulin gain weight only during the first 2-3 years after insulin introduction, The weight stabilizes thereafter. Type 2 diabetes usually remains unknown for years before diagnosisand patients may lose weight during this long period of time preceding diagnosis. It is hypothesized that the weight gain observed after the introduction of insulin may simply correspond to the reexpression of the physiologically controlled body weight.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 01:17:23