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Titolo:
Mammalian G1- and S-phase checkpoints in response to DNA damage
Autore:
Bartek, J; Lukas, J;
Indirizzi:
Danish Canc Soc, Inst Canc Biol, Dept Cell Cycle & Canc, DK-2100 Copenhagen, Denmark Danish Canc Soc Copenhagen Denmark DK-2100 , DK-2100 Copenhagen, Denmark
Titolo Testata:
CURRENT OPINION IN CELL BIOLOGY
fascicolo: 6, volume: 13, anno: 2001,
pagine: 738 - 747
SICI:
0955-0674(200112)13:6<738:MGASCI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATM-DEPENDENT PHOSPHORYLATION; EARLY EMBRYONIC LETHALITY; CELL-CYCLE ARREST; ATAXIA-TELANGIECTASIA; FUNCTIONAL-LINK; P53; PATHWAY; CANCER; BRCA1; DISRUPTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Bartek, J Danish Canc Soc, Inst Canc Biol, Dept Cell Cycle & Canc, Strandblvd 49, DK-2100 Copenhagen, Denmark Danish Canc Soc Strandblvd 49 Copenhagen Denmark DK-2100 enmark
Citazione:
J. Bartek e J. Lukas, "Mammalian G1- and S-phase checkpoints in response to DNA damage", CURR OP CEL, 13(6), 2001, pp. 738-747

Abstract

The ability to preserve genomic integrity is a fundamental feature of life. Recent findings regarding the molecular basis of the cell-cycle checkpoint responses of mammalian cells to genotoxic stress have converged into a two-wave concept of the G1 checkpoint, and shed light on the so-far elusive intra-S-phase checkpoint. Rapidly operating cascades that target the Cdc25A phosphatase appear central in both the initiation wave of the G1 checkpoint(preceding the p53-mediated maintenance wave) and the transient intra-S-phase response. Multiple links between defects in the G 1/S checkpoints, genomic instability and oncogenesis are emerging, as are new challenges and hopes raised by this knowledge.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 02:44:26