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Titolo:
Antagonists of the Src homology 2 (SH2) domains of Grb2, Src, Lck and ZAP-70
Autore:
Garcia-Echeverria, C;
Indirizzi:
Novartis Pharma AG, Oncol Res, CH-4002 Basel, Switzerland Novartis Pharma AG Basel Switzerland CH-4002 CH-4002 Basel, Switzerland
Titolo Testata:
CURRENT MEDICINAL CHEMISTRY
fascicolo: 13, volume: 8, anno: 2001,
pagine: 1589 - 1604
SICI:
0929-8673(200111)8:13<1589:AOTSH2>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRUCTURE-BASED DESIGN; CELL ANTIGEN RECEPTOR; PROTEIN-TYROSINE KINASE; AFFINITY PHOSPHOTYROSYL PEPTIDE; PHOSPHORYLATED EGF RECEPTOR; GUANINE-NUCLEOTIDE EXCHANGE; HIGHLY POTENT INHIBITORS; CONFERRING HIGH-AFFINITY; SIGNAL-TRANSDUCTION; ADAPTER PROTEIN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
123
Recensione:
Indirizzi per estratti:
Indirizzo: Garcia-Echeverria, C Novartis Pharma AG, Oncol Res, WKL-136-4-84, CH-4002 Basel, Switzerland Novartis Pharma AG WKL-136-4-84 Basel Switzerland CH-4002
Citazione:
C. Garcia-Echeverria, "Antagonists of the Src homology 2 (SH2) domains of Grb2, Src, Lck and ZAP-70", CURR MED CH, 8(13), 2001, pp. 1589-1604

Abstract

Sre homology 2 (SH2) domains are protein modules that mediate intracellular protein-protein interactions in signal transduction pathways. The specific association of an SH2 domain with a phosphotyrosine-containing sequence of another protein induces a cascade of molecular interactions that effect awide range of cellular processes. Alterations in these signaling pathways have been associated with the development and progression of a broad range of pathologies. Because of the regulatory role of SH2 domains in these signal transduction pathways, specific SH2 domains can be ideal targets for intervention with therapeutic agents in many different disease indications (e.g. cancer, osteoporosis, disorders of the immune and cardiovascular systems). Among the SH2 domains pursued as drug discovery targets in the last few years are those of Grb2, Src, Lck and ZAP-70. This review focuses on contributions in the design and synthesis of antagonists of these particular SH2 domains. Specific examples have been selected to illustrate how structure-based design approaches have been used to progress in this area of research.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:39:38