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Titolo:
Which bioengineering assay is appropriate for irritant patch testing with sodium lauryl sulfate?
Autore:
Aramaki, J; Effendy, I; Happle, R; Kawana, S; Loffler, C; Loffler, H;
Indirizzi:
Univ Marburg, Dept Dermatol, D-35033 Marburg, Germany Univ Marburg Marburg Germany D-35033 Dermatol, D-35033 Marburg, Germany Nippon Med Sch, Dept Dermatol, Tokyo 113, Japan Nippon Med Sch Tokyo Japan 113 Med Sch, Dept Dermatol, Tokyo 113, Japan
Titolo Testata:
CONTACT DERMATITIS
fascicolo: 5, volume: 45, anno: 2001,
pagine: 286 - 290
SICI:
0105-1873(200111)45:5<286:WBAIAF>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
LASER-DOPPLER FLOWMETRY; OF-CONTACT-DERMATITIS; SKIN IRRITATION; STRATUM-CORNEUM; WATER-LOSS; STANDARDIZATION-GROUP; BARRIER FUNCTION; QUANTIFICATION; GUIDELINES; INDUCTION;
Keywords:
transepidermal water loss; cutaneous blood flow; laser Doppler flowmetry; bioengineering methods; barrier disruption;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Loffler, H Univ Marburg, Dept Dermatol, Deutsch Hausstr 9, D-35033 Marburg, Germany Univ Marburg Deutsch Hausstr 9 Marburg Germany D-35033 Germany
Citazione:
J. Aramaki et al., "Which bioengineering assay is appropriate for irritant patch testing with sodium lauryl sulfate?", CONTACT DER, 45(5), 2001, pp. 286-290

Abstract

For testing with sodium lauryl sulphate (SLS), measurements of transepidermal water loss (TEWL) and cutaneous blood flow with laser Doppler (LD) are considered to be the most reliable methods. The aim of this study was to determine which method of measurement should be preferred when conducting SLStesting under varying conditions. Patch testing with SLS at different concentrations and exposure times was performed. TEWL values were compared withthose of LD. TEWL values showed distinct changes at low SLS concentrationsand short application periods. By contrast, higher SLS concentrations werenecessary to increase LD values. Short application of patches changed TEWLrather than LD values. When evaluating SLS patch testing by bioengineeringmethods, TEWL measurement appears to be more suitable for a test procedurethat provokes mild skin reactions (SLS concentration <1%), whereas LD measurement is more appropriate to evaluate pronounced skin reactions (SLS concentration greater than or equal to1%).

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Documento generato il 01/12/20 alle ore 01:12:36