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Titolo:
AN ASSOCIATION BETWEEN INCREASED SERUM-SOLUBLE INTERLEUKIN-2 RECEPTORS AND A DISTURBANCE IN MUSCLE FORCE IN SCHIZOPHRENIC-PATIENTS
Autore:
RAPAPORT MH; CALIGIURI MP; LOHR JB;
Indirizzi:
UNIV CALIF SAN DIEGO,DEPT PSYCHIAT,8950 VILLA LA JOLLA DR SUITE 2243 LA JOLLA CA 92037 SAN DIEGO VET AFFAIRS MED CTR,PSYCHIAT SERV SAN DIEGO CA 00000
Titolo Testata:
Progress in neuro-psychopharmacology & biological psychiatry
fascicolo: 5, volume: 21, anno: 1997,
pagine: 817 - 827
SICI:
0278-5846(1997)21:5<817:AABISI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEFICIENT MOTOR SYNCHRONY; TARDIVE-DYSKINESIA; SYMPTOMS; CHOREA;
Keywords:
BIOLOGICAL PSYCHIATRY; IMMUNOLOGY; MOVEMENT DISORDERS; MOVEMENT DISORDERS AND SERUM-SOLUBLE INTERLEUKIN-2 RECEPTORS; TARDIVE DYSKINESIA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
M.H. Rapaport et al., "AN ASSOCIATION BETWEEN INCREASED SERUM-SOLUBLE INTERLEUKIN-2 RECEPTORS AND A DISTURBANCE IN MUSCLE FORCE IN SCHIZOPHRENIC-PATIENTS", Progress in neuro-psychopharmacology & biological psychiatry, 21(5), 1997, pp. 817-827

Abstract

1. Serum-soluble interleukin-2 receptors (SIL-2Rs) a sign of immune activation, are increased in approximately 30% of schizophrenic subjects. 2. In a recent publication the authors found that SIL-2Rs were particularly elevated in schizophrenic subjects with tardive dyskinesia (TD). 3. This paper investigates the relationship between muscle force instability and SIL-2Rs in 32 schizophrenic patients, 10 of whom were neuroleptic-naive. 4. The authors hypothesized that there would be a positive correlation between increased levels of SIL-2Rs and muscle force instability. 5. Serum SIL-2Rs and muscle force instability were positively correlated (r = 0.54, p <.001) in the schizophrenic patients, and this correlation held even for the subset of neuroleptic-naive patients (r =.73, df 8, p =.016). 6. These findings suggest that there is an important correlation between immune activation and muscle force instability in schizophrenic patients.

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Documento generato il 07/04/20 alle ore 04:08:42