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Titolo:
5 '-Adenosine monophosphate and adenosine metabolism, and adenosine responses in mouse, rat and guinea pig heart
Autore:
Headrick, JP; Peart, J; Hack, B; Garnham, B; Matherne, GP;
Indirizzi:
Griffith Univ, NHF Res Ctr, Southport, Qld, Australia Griffith Univ Southport Qld Australia Res Ctr, Southport, Qld, Australia Univ Virginia, Hlth Sci Ctr, Dept Pediat, Charlottesville, VA USA Univ Virginia Charlottesville VA USA ept Pediat, Charlottesville, VA USA Univ Virginia, Hlth Sci Ctr, Cardiovasc Res Ctr, Charlottesville, VA USA Univ Virginia Charlottesville VA USA sc Res Ctr, Charlottesville, VA USA
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY
fascicolo: 4, volume: 130, anno: 2001,
pagine: 615 - 631
SICI:
1095-6433(200111)130:4<615:5'MAAM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL-FUNCTION; RECEPTOR OVEREXPRESSION; OXIDATIVE CAPACITY; CARDIAC MYOCYTES; SKELETAL-MUSCLE; PURINE RELEASE; MAMMALS; DEAMINASE; ISCHEMIA; VERTEBRATES;
Keywords:
adenosine; adenosine kinase; adenosine deaminase; ischemia; 5 '-nucleotidase; purines; metabolism; myocardium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Headrick, JP Griffith Univ, NHF Res Ctr, Gold Coast Campus, Southport, Qld, Australia Griffith Univ Gold Coast Campus Southport Qld Australia alia
Citazione:
J.P. Headrick et al., "5 '-Adenosine monophosphate and adenosine metabolism, and adenosine responses in mouse, rat and guinea pig heart", COMP BIOC A, 130(4), 2001, pp. 615-631

Abstract

We examined myocardial 5'-adenosine monophosphate (5'-AMP) catabolism, adenosine salvage and adenosine responses in perfused guinea pig, rat and mouse heart. Vo(2) increased from 71 +/- 8 mul O-2/min per g in guinea pig to 138 +/- 17 and 221 +/- 15 mul O-2/min per g in rat and mouse. Vo(2)/beat was0.42 +/- 0.03, 0.50 +/- 0.03 and 0.55 +/- 0.04 mul O-2/g in guinea pig, rat and mouse, respectively. Resting and peak coronary flows were highest in mouse vs. rat and guinea pig, and peak ventricular pressures and Ca2+ sensitivity declined as heart mass increased. Net myocardial 5'-AMP dephosphorylation increased significantly as mass declined (3.8 +/- 0.5, 9.0 +/- 1.4 and 11.0 +/- 1.6 nmol/min per g in guinea pig, rat and mouse, respectively). Despite increased 5'-AMP catabolism, coronary venous [adenosine] was similar in guinea pig, rat and mouse (45 +/- 8, 69 +/- 10 and 57 +/- 14 nM, respectively). Comparable venous [adenosine] was achieved by increased salvage vs. deamination: 64%, 41% and 39% of adenosine formed was rephosphorylated while 23%, 46%, and 50% was deaminated in mouse, rat and guinea pig, respectively. Moreover, only 35-45% of inosine and its catabolites derive from 5'-AMP (vs. IMP) dephosphorylation in all species. Although post-ischemic purine loss was low in mouse (due to these adaptations), functional tolerance to ischemia decreased with heart mass. Cardiovascular sensitivity to adenosine also differed between species, with A, receptor sensitivity being greatest in mouse while A(2) sensitivity was greatest in guinea pig. In summary: (i) cardiac 5'-AMP dephosphorylation, Vo(2), contractility and Ca2+ sensitivity all increase as heart mass falls; (ii) adaptations in adenosine salvage vs. deamination limit purine loss and yield similar adenosine levels across species; (iii) ischemic tolerance declines with heart mass; and (iv) cardiovascular sensitivity to adenosine varies, with increasing A(2) sensitivity relative to A(1) sensitivity in larger hearts. (C) 2001 Elsevier ScienceInc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:56:23