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Titolo:
Calcitonin gene-related peptide (CGRP) and the pathophysiology of headache- Therapeutic implications
Autore:
Edvinsson, L;
Indirizzi:
Univ Lund Hosp, Dept Internal Med, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 pt Internal Med, S-22185 Lund, Sweden
Titolo Testata:
CNS DRUGS
fascicolo: 10, volume: 15, anno: 2001,
pagine: 745 - 753
SICI:
1172-7047(2001)15:10<745:CGP(AT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVITY-MODIFYING PROTEINS; RECEPTOR-LIKE RECEPTOR; HUMAN CEREBRAL-ARTERIES; NERVE-FIBERS; EXTRACEREBRAL CIRCULATION; TRIGEMINOVASCULAR SYSTEM; NEUROPEPTIDE CHANGES; CLUSTER HEADACHE; FUNCTIONAL-ROLE; BINDING-SITES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Edvinsson, L Univ Lund Hosp, Dept Internal Med, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 ed, S-22185 Lund, Sweden
Citazione:
L. Edvinsson, "Calcitonin gene-related peptide (CGRP) and the pathophysiology of headache- Therapeutic implications", CNS DRUGS, 15(10), 2001, pp. 745-753

Abstract

Cerebral blood vessels are innervated by sensory nerves that store severalneurotransmitters. In primary headaches, there is a clear association between head pain and the release of the neuropeptide calcitonin gene-related peptide (CGRP). Furthermore, when triptan antimigraine agents are administered, headache subsides and the neuropeptide release normalises, in part via a presynaptic effect. The central role of CGRP in primary headaches has ledto the search for suitable antagonists of the receptors for this neuropeptide, which it is hoped will have less cardiovascular adverse effects than the triptans. Recently, the initial pharmacological profile of such a group of compounds has been disclosed. These compounds are small molecules with high selectivity for human CGRP receptors. Hypothetically, these agents willbe efficacious in the relief of migraine headaches via blockade of the effects of CGRP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:29:16