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Titolo:
Perception of bronchoconstriction in smokers with airflow limitation
Autore:
Ottanelli, R; Rosi, E; Ronchi, MC; Grazzini, M; Lanini, B; Stendardi, L; Romagnoli, I; Bertini, S; Duranti, R; Scano, G;
Indirizzi:
Univ Florence, Dept Internal Med, Sect Clin Immunol & Resp Dis, I-50134 Florence, Italy Univ Florence Florence Italy I-50134 & Resp Dis, I-50134 Florence, Italy Fdn Don C Gnocchi IRCCS, Pozzolatico, Florence, Italy Fdn Don C Gnocchi IRCCS Pozzolatico Florence Italy tico, Florence, Italy
Titolo Testata:
CLINICAL SCIENCE
fascicolo: 5, volume: 101, anno: 2001,
pagine: 515 - 522
SICI:
0143-5221(200111)101:5<515:POBISW>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSTRUCTIVE PULMONARY-DISEASE; CHRONIC LUNG-DISEASE; RESPIRATORY SENSATION; ASTHMA; BREATHLESSNESS; METHACHOLINE; CHALLENGE; DYSPNEA; INFLAMMATION; MECHANISMS;
Keywords:
Borg; chronic airflow obstruction; dyspnoea; bronchial hyper-responsiveness;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Scano, G Univ Florence, Dept Internal Med, Sect Clin Immunol & Resp Dis, I-50134 Florence, Italy Univ Florence Florence Italy I-50134 s, I-50134 Florence, Italy
Citazione:
R. Ottanelli et al., "Perception of bronchoconstriction in smokers with airflow limitation", CLIN SCI, 101(5), 2001, pp. 515-522

Abstract

To our knowledge, no data have been provided as to whether and to what extent dynamic hyperinflation, through its deleterious effect on inspiratory muscle function, affects the perception of dyspnoea during induced bronchoconstriction in patients with chronic airflow obstruction. We hypothesized that dynamic hyperinflation accounts in part for the variability in dyspnoea during acute bronchoconstriction. We therefore studied 39 consecutive clinically stable patients whose pulmonary function data were as follows (% of predicted value): vital capacity (VC), 97.8% (S.D. 16.0%); functional residual capacity, 105.0% (18.8%); actual forced expiratory volume in I s (FEVI)/VC ratio, 56.1% (6.3%). Perception of dyspnoea using the Borg scale was assessed during a methacholine-induced fall in FEVI. The clinical score and the treatment score, the level of bronchial hyper-responsiveness and the cytological sputum differential count were also assessed. In each patient, the percentage fall in FEV, and the concurrent Borg rating were linearly related, with the mean slope (PD slope) being 0.09 (0.06). The percentage fall inFEVI accounted for between 41% and 94% of the variation in the Borg score. At a 20% fall in FEVI, the decrease in inspiratory capacity (AIC) was 0.156 (0.050) litres. Patients were divided into three subgroups according to the PD slope (arbitrary units/% fall in FEVI): subgroup I [eight hypoperceivers; PD slope 0.026 (0.005)], subgroup II [26 moderate perceivers; 0.090 (0.037)] and subgroup III [five hyperperceivers; 0.200 (0.044)]. By applying stepwise multiple regression analysis with the PD slope as the dependent variable; and other characteristics (demographic, clinical and functional characteristics, smoking history, level of bronchial hyper-responsiveness and sputum cytological profile) as independent variables, AIC (r(2) = 45%, P < 0.00001) and to a lesser extent treatment score (r(2) = 17.3%, P < 0.0006),and to an even lesser extent age (r(2) = 3%, P < 0.05), independently predicted a substantial amount (r(2) = 65.27%, P < 0.00001) of the variability in the Borg slope. Thus acute hyperinflation, and to a lesser extent treatment score and age, account in part for the variability in the perception ofdyspnoea after accounting for changes in FEVI during bronchoconstriction in patients with chronic airflow obstruction.

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Documento generato il 25/02/20 alle ore 11:07:44