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Titolo:
Interferon therapy in hemodialysis patients with chronic hepatitis C virusinfection induces a high rate of long-term sustained virological and biochemical response
Autore:
Espinosa, M; Rodriguez, M; Martin-Malo, A; de Lara, MAA; Gonzalez, R; Lopez-Rubio, F; de la Mata, M; Aljama, P;
Indirizzi:
Hosp Univ Reina Sofia, Serv Nefrol, Cordoba 14004, Spain Hosp Univ Reina Sofia Cordoba Spain 14004 v Nefrol, Cordoba 14004, Spain Hosp Univ Reina Sofia, Serv Immunol, Cordoba 14004, Spain Hosp Univ Reina Sofia Cordoba Spain 14004 Immunol, Cordoba 14004, Spain Hosp Univ Reina Sofia, Serv Anat Patol, Cordoba 14004, Spain Hosp Univ Reina Sofia Cordoba Spain 14004 at Patol, Cordoba 14004, Spain Hosp Univ Reina Sofia, Unidad Hepatol, Cordoba 14004, Spain Hosp Univ Reina Sofia Cordoba Spain 14004 Hepatol, Cordoba 14004, Spain
Titolo Testata:
CLINICAL NEPHROLOGY
fascicolo: 3, volume: 55, anno: 2001,
pagine: 220 - 226
SICI:
0301-0430(200103)55:3<220:ITIHPW>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIALYSIS PATIENTS; RENAL-FAILURE; NON-A; ALPHA; COMBINATION; TOLERANCE; RIBAVIRIN; EFFICACY; VIREMIA; RNA;
Keywords:
hepatitis C virus (HCV); HCV-RNA; hemodialysis; interferon liver; disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Espinosa, M Hosp Univ Reina Sofia, Serv Nefrol, Avda Menendez Pidal S-N, Cordoba 14004, Spain Hosp Univ Reina Sofia Avda Menendez Pidal S-N Cordoba Spain 14004
Citazione:
M. Espinosa et al., "Interferon therapy in hemodialysis patients with chronic hepatitis C virusinfection induces a high rate of long-term sustained virological and biochemical response", CLIN NEPHR, 55(3), 2001, pp. 220-226

Abstract

Aim: The aim of the present study was to analyze the efficacy and tolerance of interferon (IFN) therapy in hemodialysis (HD) patients with chronic hepatitis C virus (HCV) infection. Specifically, we assessed whether the "normalization" of serum ALT levels was associated with the disappearance of the HCV-RNA. Methods: Thirteen hemodialysis patients with chronic hepatitis Cwere treated for one year with 3 MU of cc-IFN. The primary end point was asustained virological response defined as the absence of HCV-RNA in the last follow-up; the secondary end points were normalization of the serum ALT levels and histological improvement. ALT was considered "normal" below 27 IU/1. Results: Ten patients completed the treatment, which was discontinued in the other 3 (23%). By the end of the treatment a virological response was observed in 8 of the 10 patients (80%) who completed the one-year IFN therapy. Biochemical response was associated with a virological response in 8 of the 9 patients in whom ALT levels became normal. Three patients had a biochemical and virological relapse in the follow-up. Two of them received a further year of IFN therapy, which resulted in a sustained biochemical and virological response. In all patients who underwent a liver biopsy (n = 5),the inflammation score improved. After a median follow-up of 5 years (range 2 - 7), a sustained response was observed in 6 (46%) of the 13 patients enrolled. Two patients with a sustained response received a kidney transplant and after more than 6 years still maintain a biochemical and virological response. Side effects included flu-like syndrome (n = 8), hemoglobin decrease (n = 8), thrombocytopenia (n = 3), depression (n = 1) and seizures (n =1). Conclusion: IFN treatment over a one-year period produces a high rate of long-term virological response in HD patients, associated to a biochemical response in all cases.

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Documento generato il 31/03/20 alle ore 19:11:11