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Titolo:
Urinary type IV collagen excretion reflects renal morphological alterations and type IV collagen expression in patients with type 2 diabetes mellitus
Autore:
Okonogi, H; Nishimura, M; Utsunomiya, Y; Hamaguchi, K; Tsuchida, H; Miura, Y; Suzuki, S; Kawamura, T; Hosoya, T; Yamada, K;
Indirizzi:
Sakura Natl Hosp, Dept Internal Med, Sakura, Chiba 2858765, Japan Sakura Natl Hosp Sakura Chiba Japan 2858765 Sakura, Chiba 2858765, Japan Sakura Natl Hosp, Dept Pathol, Sakura, Chiba 2858765, Japan Sakura Natl Hosp Sakura Chiba Japan 2858765 Sakura, Chiba 2858765, Japan Jikei Univ, Sch Med, Dept Internal Med 2, Tokyo, Japan Jikei Univ Tokyo Japan Univ, Sch Med, Dept Internal Med 2, Tokyo, Japan
Titolo Testata:
CLINICAL NEPHROLOGY
fascicolo: 5, volume: 55, anno: 2001,
pagine: 357 - 364
SICI:
0301-0430(200105)55:5<357:UTICER>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SANDWICH ENZYME-IMMUNOASSAY; MESANGIAL CELLS; BASEMENT-MEMBRANE; HIGH GLUCOSE; RISK-FACTORS; NEPHROPATHY; GLOMERULOSCLEROSIS; PATTERNS; INCREASE; LESIONS;
Keywords:
diabetic nephropathy; type IV collagen; extracellular matrix;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Nishimura, M Sakura Natl Hosp, Dept Internal Med, 2-36-2,Ebaradai, Sakura,Chiba 2858765, Japan Sakura Natl Hosp 2-36-2,Ebaradai Sakura Chiba Japan 2858765 n
Citazione:
H. Okonogi et al., "Urinary type IV collagen excretion reflects renal morphological alterations and type IV collagen expression in patients with type 2 diabetes mellitus", CLIN NEPHR, 55(5), 2001, pp. 357-364

Abstract

Aim: We tried to establish the significance of quantifying urinary type IVcollagen (W-C) excretion for the evaluation of renal involvement of type 2-diabetic patients. Methods: Twenty patients (13 males and 7 females, age range 31 to 69 years) with type 2 diabetes mellitus had undergone renal biopsy and relationship between the severity of morphological alteration, IV-C expression and urinary IV-C excretion were examined. Results. Urinary IV-C excretion significantly correlated with mesangial expansion score (rho = 0.49, p < 0.05) and tubulointerstitial injury score (rho = 0.56, p < 0.05). Furthermore, urinary IV-C excretion significantly correlated with both glomerular (r = 0.56, p < 0.01) and tubulointerstitial IV-C expression areas. Urinary protein excretion also correlated with mesangial expansion score and tubulointerstitial injury score. However, it did not correlate with the expression of IV-C in the kidney. Conclusions: These results suggest that urinary IV-C excretion reflects the pathogenetic process of diabetic nephropathy, which urinary protein excretion alone cannot do sufficiently. It can be concluded that urinary IV-C excretion could be a more useful marker for theevaluation of renal involvement of type 2-diabetic patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 16:00:41