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Titolo:
Profiling hemodialysis patients with high ferritin levels
Autore:
Kirschbaum, B;
Indirizzi:
Virginia Commonwealth Univ, Dept Internal Med, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA
Titolo Testata:
CLINICAL NEPHROLOGY
fascicolo: 2, volume: 56, anno: 2001,
pagine: 117 - 123
SICI:
0301-0430(200108)56:2<117:PHPWHF>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-REACTIVE PROTEIN; IRON-DEFICIENT ERYTHROPOIESIS; ZINC PROTOPORPHYRIN; MYOCARDIAL-INFARCTION; SERUM FERRITIN; HEART-DISEASE; RISK; ATHEROSCLEROSIS; CORONARY; INFLAMMATION;
Keywords:
ferritin; zinc protoporphyrin; C-reactive protein; hemodialysis anemia; cluster analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Kirschbaum, B Virginia Commonwealth Univ, Dept Internal Med, Box 980160, Richmond, VA 23298 USA Virginia Commonwealth Univ Box 980160 Richmond VA USA23298
Citazione:
B. Kirschbaum, "Profiling hemodialysis patients with high ferritin levels", CLIN NEPHR, 56(2), 2001, pp. 117-123

Abstract

Aims: Hemodialysis patients receiving intravenous iron and erythropoietin may develop greatly elevated ferritin levels. Both iron overload and inflammation may account for this hyperferritinemia. The aim of this study was totry to identify the cause of the high ferritin level among individual patients. Methods: Sixty-seven chronic hemodialysis patients with ferritn levels < 700 mug/l were compared to 47 patients whose ferritin levels were greater than or equal to 700 mug/l. Clinical and laboratory data were collected and evaluated by cluster analysis which allowed patients to be placed into statistically dissimilar groups. Results: The 47 high ferritin patients segregated into 3 clusters consisting of 28, 3, and 16 patients based on ferritin, zinc protoporphyrin, albumin, C-reactive protein, and hemoglobin. Whencontrasted with cluster 1, cluster 3 patients had higher levels of Zn-PP, CRP, and ferritin and lower levels of albumin and hemoglobin. Conclusions: Utilizing these data and the results of many other studies, we conclude that, relative to cluster 1, cluster 3 patients had a more intense inflammatory response that blocked iron mobilization required for erythrocyte production. Cluster analysis appears to be a useful method of analyzing clinical data of relatively small patient population.

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Documento generato il 22/01/20 alle ore 06:54:08