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Titolo:
Enhancement of red blood cell aggregation by plasma triglycerides
Autore:
Cicha, I; Suzuki, Y; Tateishi, N; Maeda, N;
Indirizzi:
Ehime Univ, Sch Med, Dept Physiol, Shigenobu, Ehime 7910295, Japan Ehime Univ Shigenobu Ehime Japan 7910295 Shigenobu, Ehime 7910295, Japan Ehime Univ Hosp, Dept Med Informat, Shigenobu, Ehime 7910295, Japan Ehime Univ Hosp Shigenobu Ehime Japan 7910295 enobu, Ehime 7910295, Japan
Titolo Testata:
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
fascicolo: 4, volume: 24, anno: 2001,
pagine: 247 - 255
SICI:
1386-0291(2001)24:4<247:EORBCA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ERYTHROCYTE AGGREGATION; FATTY-ACIDS; CHOLESTEROL; FIBRINOGEN; RHEOLOGY; SERUM;
Keywords:
red blood cells; red blood cell aggregation; plasma triglycerides;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Maeda, N Ehime Univ, Sch Med, Dept Physiol, Shigenobu, Ehime 7910295, Japan Ehime Univ Shigenobu Ehime Japan 7910295 u, Ehime 7910295, Japan
Citazione:
I. Cicha et al., "Enhancement of red blood cell aggregation by plasma triglycerides", CL HEMORH M, 24(4), 2001, pp. 247-255

Abstract

The effects of plasma triglycerides level on human red blood cells (RBCs) indices, hematological parameters, RBCs aggregation velocity and whole blood viscosity were studied at 2 hours after high-fat or low-fat meal. Proteins, triglycerides and cholesterol levels of plasma were analysed. The RBCs rouleaux formation rate was measured in 70% autologous plasma (with 30% phosphate-buffered saline, PBS) or 1 g/dl dextran T70 solution (with 4 g/dl bovine serum albumin) in PBS, using a low-shear rheoscope. The results were grouped according to triglycerides content in plasma. No significant difference in whole blood viscosity, hematological parameters, RBC indices, proteinand cholesterol content was observed between high-fat and low-fat blood samples. There was a significant increase in rouleaux formation rate of samples with high triglyceride levels, when measured in 70% autologous plasma, but it was not significant in dextran T70 containing medium. In conclusion, the results obtained suggest that alteration of plasma lipid levels as wellas possible changes in the cell membrane lipid composition lead to enhanced RBC aggregation.

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Documento generato il 24/10/20 alle ore 11:43:26