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Titolo:
Nitric oxide, prostanoids, cyclooxygenase, and angiogenesis in colon and breast cancer
Autore:
Bing, RJ; Miyataka, M; Rich, KA; Hanson, N; Wang, XD; Slosser, HD; Shi, SR;
Indirizzi:
Huntington Med Res Inst, Dept Expt Cardiol, Pasadena, CA 91101 USA Huntington Med Res Inst Pasadena CA USA 91101 iol, Pasadena, CA 91101 USA Huntington Mem Hosp, Dept Pathol, Pasadena, CA 91109 USA Huntington Mem Hosp Pasadena CA USA 91109 Pathol, Pasadena, CA 91109 USA Univ So Calif, Dept Pathol, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 Pathol, Los Angeles, CA 90033 USA
Titolo Testata:
CLINICAL CANCER RESEARCH
fascicolo: 11, volume: 7, anno: 2001,
pagine: 3385 - 3392
SICI:
1078-0432(200111)7:11<3385:NOPCAA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ENDOTHELIAL GROWTH-FACTOR; COLORECTAL-CANCER; ADENOMATOUS POLYPOSIS; TUMOR ANGIOGENESIS; THROMBOXANE A(2); GENE-EXPRESSION; CELL-LINES; SYNTHASE; CELECOXIB;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Bing, RJ Huntington Med Res Inst, Dept Expt Cardiol, 99 N El Molino Ave, Pasadena, CA 91101 USA Huntington Med Res Inst 99 N El Molino Ave Pasadena CA USA 91101
Citazione:
R.J. Bing et al., "Nitric oxide, prostanoids, cyclooxygenase, and angiogenesis in colon and breast cancer", CLIN CANC R, 7(11), 2001, pp. 3385-3392

Abstract

Purpose: Several studies have shown an overexpression of cyclooxygenase-2 (COX-2) and elevated levels of prostacyclin (PGI(2)) and thromboxane (TXA(2)) in colon cancer. In this report, we determined the distribution of inducible form of nitric oxide synthase (iNOS), PGI(2), and TXA(2) in cancerous and adjoining areas of specimens from human colon and breast cancer obtained during surgery. Additionally, we investigated differences in expression and histological localization of COX-2 in colon and breast cancer. Experimental Design: Specimens were obtained during surgery, one centrallylocated, the second from an adjacent, cancer-free area. Activity of iNOS was determined, using the conversion of L-[C-14]arginine to L-[C-14]citrulline. PGI(2) and TXA(2) were measured as their stable metabolites, using enzyme immunoassay. A standard immunoperoxidase method was used for immunohistochemical expression of COX-2. Results: Significant differences in iNOS, PGI(2), and TXA(2) expressions between colon and breast cancer were noted, with an enhanced expression of COX-2 in colon cancer, including the cancerous, adjoining, and stromatous fields. Conclusions: Increased expression of iNOS and production of prostanoids incolon cancer parallels the increase in COX-2, confirming the importance ofthis enzyme in colon cancer. The overexpression of COX-2, prostanoids, andnitric oxide in areas adjoining the tumor indicates increased metastatic potential for neoplastic cells in this area. Inflammatory changes in the tissue adjoining the cancer may play a role. COX-2 may result in the formationof new blood vessels and the spread of cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:39:31