Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Perivascular inflammation after balloon angioplasty of porcine coronary arteries
Autore:
Okamoto, E; Couse, T; De Leon, H; Vinten-Johansen, J; Goodman, RB; Scott, NA; Wilcox, JN;
Indirizzi:
Emory Univ, Dept Surg, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 ry Univ, Dept Surg, Atlanta, GA 30322 USA Emory Univ, Dept Med, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 ory Univ, Dept Med, Atlanta, GA 30322 USA Univ Washington, Dept Med, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ton, Dept Med, Seattle, WA 98195 USA Emory Univ, Div Hematol Oncol, Winship Canc Inst, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 Winship Canc Inst, Atlanta, GA 30322 USA
Titolo Testata:
CIRCULATION
fascicolo: 18, volume: 104, anno: 2001,
pagine: 2228 - 2235
SICI:
0009-7322(20011030)104:18<2228:PIABAO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCYTE CHEMOATTRACTANT PROTEIN-1; CELL-ADHESION MOLECULE-1; INTIMAL HYPERPLASIA; VASA VASORUM; MONOCLONAL-ANTIBODIES; POTENTIAL ROLE; INJURY; EXPRESSION; ACTIVATION; RAT;
Keywords:
angioplasty; inflammation; cell adhesion molecules; remodeling; restenosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Wilcox, JN Emory Univ, Div Hematol Oncol, Winship Canc Inst, 1639 Pierce Dr,Room 1115WMRB, Atlanta, GA 30322 USA Emory Univ 1639 Pierce Dr,Room 1115 WMRB Atlanta GA USA 30322 A
Citazione:
E. Okamoto et al., "Perivascular inflammation after balloon angioplasty of porcine coronary arteries", CIRCULATION, 104(18), 2001, pp. 2228-2235

Abstract

Background-Inflammation has been suggested to play a role in vascular lesion formation after angioplasty. Whereas previous studies have focused on inflammatory reactions in the intima and media, less attention has been paid to adventitial and perivascular responses and their potential role in vascular remodeling. Methods and Results-Balloon overstretch injury of porcine coronary arteries was performed with standard clinical angioplasty catheters. Vessels were examined from 0.5 hour to 14 days after injury by immunohistochemistry and in situ hybridization (ISH) for neutrophil and macrophage markers, cell adhesion molecules (P-selectin, E-selectin, and vascular cell adhesion molecule-1), and neutrophil-specific CXC chemokines (alveolar macrophage-derived neutrophil chemotactic factor [AMCF]-I/interleukin-8 and AMCF-II). Neutrophils accumulated in the adventitia surrounding the injury site from 2 hours to 3 days, followed by macrophages from I to 7 days after angioplasty, Inflammation was associated temporally with the expression of mRNAs encoding cell adhesion molecules and chemokines. The main inflammatory and proliferative foci were not limited to the adventitia but rather extended many millimeters away from the injured vessel throughout the surrounding adipose and myocardial tissues. Conclusions-Inflammatory responses after angioplasty of porcine coronary arteries occurred throughout the entire perivascular tissue. We hypothesize that perivascular inflammatory cells play a role in the recruitment and/or proliferation of adventitial myofibroblasts, possibly through the release of reactive oxygen species and/or cytokines, and thus contribute to vascularremodeling associated with postangioplasty restenosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:40:33