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Titolo:
Coupling the use of computer chemical speciation models and culture techniques in laboratory investigations of trace metal toxicity
Autore:
Twiss, MR; Errecalde, O; Fortin, C; Campbell, PGC; Jumarie, C; Denizeau, F; Berkelaar, E; Hale, B; van Rees, K;
Indirizzi:
Ryerson Polytech Univ, Dept Chem Biol & Chem Engn, Toronto, ON M5B 2K3, Canada Ryerson Polytech Univ Toronto ON Canada M5B 2K3 ronto, ON M5B 2K3, Canada Labs Aeterna Inc, St Foy, PQ G1N 4A8, Canada Labs Aeterna Inc St Foy PQ Canada G1N 4A8 Inc, St Foy, PQ G1N 4A8, Canada Inst Protect & Surete Nucl, Dept Protect Environm, F-13108 St Paul Les Durance, France Inst Protect & Surete Nucl St Paul Les Durance France F-13108 ce, France Univ Quebec, INRS Eau, St Foy, PQ G1V 4C7, Canada Univ Quebec St Foy PQ Canada G1V 4C7 INRS Eau, St Foy, PQ G1V 4C7, Canada Univ Quebec, Dept Sci Biol, Montreal, PQ H3C 3P8, Canada Univ Quebec Montreal PQ Canada H3C 3P8 Biol, Montreal, PQ H3C 3P8, Canada Univ Quebec, Dept Chim, Montreal, PQ H3C 3P8, Canada Univ Quebec MontrealPQ Canada H3C 3P8 Chim, Montreal, PQ H3C 3P8, Canada Univ Guelph, Dept Land Resource Sci, Guelph, ON N1G 2W1, Canada Univ Guelph Guelph ON Canada N1G 2W1 urce Sci, Guelph, ON N1G 2W1, Canada Univ Saskatchewan, Dept Soil Sci, Saskatoon, SK S7N 5B3, Canada Univ Saskatchewan Saskatoon SK Canada S7N 5B3 skatoon, SK S7N 5B3, Canada
Titolo Testata:
CHEMICAL SPECIATION AND BIOAVAILABILITY
fascicolo: 1, volume: 13, anno: 2001,
pagine: 9 - 24
SICI:
0954-2299(2001)13:1<9:CTUOCC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-MOLECULAR-WEIGHT; RAINBOW-TROUT GILLS; SELENASTRUM-CAPRICORNUTUM; NUTRIENT SOLUTIONS; COPPER TOXICITY; CADMIUM UPTAKE; SWISS-CHARD; GREEN-ALGA; IN-VITRO; DIATOM THALASSIOSIRA;
Keywords:
chemical equilibrium modelling; bioassay; methodology; experimental design;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
92
Recensione:
Indirizzi per estratti:
Indirizzo: Campbell, PGC Ryerson Polytech Univ, Dept Chem Biol & Chem Engn, 350 Victoria St, Toronto, ON M5B 2K3, Canada Ryerson Polytech Univ 350 Victoria St Toronto ON Canada M5B 2K3
Citazione:
M.R. Twiss et al., "Coupling the use of computer chemical speciation models and culture techniques in laboratory investigations of trace metal toxicity", CHEM SPEC B, 13(1), 2001, pp. 9-24

Abstract

The bioavailability and toxicity of a dissolved metal are closely linked to the metal's chemical speciation In solution A variety of inorganic and organic ligands are often used in laboratory toxicity tests to control the concentration of labile trace metal in solution. Computerised chemical speciation models based on thermodynamic principles can be used to estimate metalspeciation under such experimental conditions. However, these models are sensitive to the quality of their thermodynamic databases. Detailed protocols for the incorporation of reliable equilibrium formation constants into widely available computer chemical speciation programs (e.g., MINEQL+ and MINTEQ) are provided. The examples demonstrate both the benefits and the potential pitfalls involved in the use of chemical speciation models. The application of chemical speciation modelling to metal toxicity studies is discussed and guidelines are proposed for its proper use. Both defined media and chemical speciation programs have co-existed for two decades but the combined use of these techniques has been reserved for those possessing in-depth knowledge of both chemistry and biology. The techniques presented should enable an investigator with basic biological, chemical and computing skills todesign an aqueous medium and incorporate correct thermodynamic constants into a computer chemical speciation program, starting from a standardised database, thereby providing a sound framework for critically assessing the biological response of a particular test organism to a given metal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 21:59:31