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Titolo:
TC-99M SESTAMIBI LEG SCINTIGRAPHY FOR NONINVASIVE ASSESSMENT OF PROPIONYL-L-CARNITINE INDUCED CHANGES IN SKELETAL-MUSCLE METABOLISM
Autore:
CITTANTI C; COLAMUSSI P; GIGANTI M; ORLANDI C; UCCELLI L; MANFRINI S; AZZENA G; PIFFANELLI A;
Indirizzi:
UNIV FERRARA,DEPT NUCL MED,CSO GIOVECCA 203 I-44100 FERRARA ITALY MEDCO RES INC RES TRIANGLE PK NC 27709 UNIV FERRARA,SURG PATHOL INST I-44100 FERRARA ITALY
Titolo Testata:
European journal of nuclear medicine
fascicolo: 7, volume: 24, anno: 1997,
pagine: 762 - 766
SICI:
0340-6997(1997)24:7<762:TSLSFN>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL ARTERIAL-DISEASE; DOUBLE-BLIND; SUBCELLULAR-DISTRIBUTION; VASCULAR-DISEASE; RAT HEARTS; MITOCHONDRIAL; ISONITRILE; PROTECTION; MYOCARDIUM; PERFUSION;
Keywords:
OBSTRUCTIVE PERIPHERAL ARTERY DISEASE; MUSCLE PERFUSION; SCINTIGRAPHY; TC-99M-SESTAMIBI; DOPPLER SONOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
C. Cittanti et al., "TC-99M SESTAMIBI LEG SCINTIGRAPHY FOR NONINVASIVE ASSESSMENT OF PROPIONYL-L-CARNITINE INDUCED CHANGES IN SKELETAL-MUSCLE METABOLISM", European journal of nuclear medicine, 24(7), 1997, pp. 762-766

Abstract

Carnitine derivatives, such as propionyl-L-carnitine (PLC), have beenshown to improve walking distance in patients with obstructive peripheral artery disease (PAOD). The aim of this study was to ascertain whether technetium-99m sestamibi leg scintigraphy may be a useful tool inthe evaluation of changes in skeletal muscle metabolism induced by chronic therapy with PLC. Twenty patients with clinical and instrumentalevidence of PAOD were randomly assigned to a 3-month period of therapy with either PLC or placebo. Rest Tc-99m-sestamibi leg scintigraphy and echo-Doppler sonography were performed on all subjects immediately before and upon completion of the treatment period. At the end of the protocol the following results were observed in patients who underwentPLC administration: (a) a significant increase in both thigh and calfTc-99m-sestamibi uptake, in comparison with baseline values (P<0.001); (b) the absence of statistically significant modifications of Doppler blood flow indices of the lower limbs. In conclusion, after chronic administration of PLC, a significant increment in skeletal muscle uptake of Tc-99m-sestamibi was demonstrated without any apparent change inregional blood flow. This fact, if proven in further studies, may suggest a role for this tracer as a non-invasive probe of tissue bioenergetics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 07:53:36