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Titolo:
Quinapril with high affinity to tissue angiotensin-converting enzyme reduces restenosis after percutaneous transcatheter coronary intervention
Autore:
Okimoto, T; Imazu, M; Hayashi, Y; Gomyo, Y; Sekiguchi, Y; Yanagihara, K; Shimohara, Y; Sumii, K; Yamamoto, H; Tadehara, F; Toyofuku, M; Kohno, N;
Indirizzi:
Hiroshima Univ, Fac Med, Dept Internal Med 2, Minami Ku, Hiroshima 7348551, Japan Hiroshima Univ Hiroshima Japan 7348551 nami Ku, Hiroshima 7348551, Japan Tsuchiya Gen Hosp, Hiroshima, Japan Tsuchiya Gen Hosp Hiroshima JapanTsuchiya Gen Hosp, Hiroshima, Japan Mazda Hosp, Hiroshima, Japan Mazda Hosp Hiroshima JapanMazda Hosp, Hiroshima, Japan Hiroshima Gen Hosp, Hiroshima, Japan Hiroshima Gen Hosp Hiroshima JapanHiroshima Gen Hosp, Hiroshima, Japan Hiroshima Natl Hosp, Higashihiroshima, Japan Hiroshima Natl Hosp Higashihiroshima Japan osp, Higashihiroshima, Japan Kure Kyosai Hosp, Kure, Japan Kure Kyosai Hosp Kure JapanKure Kyosai Hosp, Kure, Japan
Titolo Testata:
CARDIOVASCULAR DRUGS AND THERAPY
fascicolo: 4, volume: 15, anno: 2001,
pagine: 323 - 329
SICI:
0920-3206(200107)15:4<323:QWHATT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR INJURY; HYPERTENSIVE PATIENTS; ENDOTHELIAL FUNCTION; ANGIOPLASTY; INHIBITION; TRIAL; CAPTOPRIL; ARTERIES; ACE; ATHEROSCLEROSIS;
Keywords:
ACE inhibitor; coronary; quinapril; restenosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Okimoto, T Hiroshima Univ, Fac Med, Dept Internal Med 2, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan Hiroshima Univ 1-2-3 Kasumi Hiroshima Japan 7348551 551, Japan
Citazione:
T. Okimoto et al., "Quinapril with high affinity to tissue angiotensin-converting enzyme reduces restenosis after percutaneous transcatheter coronary intervention", CARDIO DRUG, 15(4), 2001, pp. 323-329

Abstract

Experimental studies have demonstrated that vascular injury resulted in aninduction of vascular angiotensin-converting enzyme (ACE), and have suggested that inhibition of vascular ACE might be important in the prevention ofrestenosis. The present study aimed to determine the effect of quinapril, an ACE inhibitor with high affinity to tissue ACE, on restenosis following coronary intervention. The design of this study was a prospective, randomized, open, and non-placebo controlled trial. Patients with ischemic heart disease were enrolled after successful percutaneous transluminal coronary angioplasty or stent implantation at 7 participating institutions. Two hundredand fifty-three patients with 294 lesions were randomly assigned to the quinapril (10-20 mg per day) group or control group. Administration of quinapril was continued for 3-6 months of the follow-up. Quantitative coronary angiography was performed before and after angioplasty and at follow-up. Corelaboratory measurements were performed independently and blinded. Follow-up angiography was performed in 108 patients with 124 lesions in the quinapril group and in 107 patients with 130 lesions in the control group. The baseline characteristics and findings of angioplasty showed no significant differences between the two groups. However, in the quinapril group, restenosis per patient and per lesion was significantly lower (34.3% vs. 47.7%, p < 0.05 and 30.6% vs. 43.8%, p < 0.05). Multivariable analysis revealed that administration of quinapril independently contributed to reducing the restenosis per patient and per lesion (odds ratio, 0.73; 95% confidence interval,0.54-0.99 and odds ratio, 0.75; 95% confidence interval, 0.57-0.99). In conclusion, quinapril significantly reduces restenosis following coronary intervention.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 00:40:30