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Titolo:
ACE-inhibition plus mineralocorticoid antagonism versus ACE-inhibition alone in patients with anterior myocardial infarction
Autore:
Di Pasquale, P; Cannizzaro, S; Scandurra, A; Giubilato, A; Scalzo, S; Paterna, S;
Indirizzi:
GF Ingrassia Hosp, Div Cardiol Paolo Borsellino, I-90144 Palermo, Italy GFIngrassia Hosp Palermo Italy I-90144 rsellino, I-90144 Palermo, Italy Civ Hosp, Div Anaesthesiol, Palermo, Italy Civ Hosp Palermo ItalyCiv Hosp, Div Anaesthesiol, Palermo, Italy Univ Palermo, Dept Internal Med, I-90133 Palermo, Italy Univ Palermo Palermo Italy I-90133 Internal Med, I-90133 Palermo, Italy
Titolo Testata:
CARDIOVASCULAR DRUGS AND THERAPY
fascicolo: 4, volume: 15, anno: 2001,
pagine: 309 - 314
SICI:
0920-3206(200107)15:4<309:APMAVA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING ENZYME-INHIBITOR; CONGESTIVE-HEART-FAILURE; ALDOSTERONE; SPIRONOLACTONE; RENIN; BIOSYNTHESIS; THERAPY; HYPERTENSION; HYPERTROPHY; BLOCKADE;
Keywords:
myocardial infarction; aldosterone; canreonate; echocardiography; cardiac volumes; diastolic function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Di Pasquale, P GF Ingrassia Hosp, Div Cardiol Paolo Borsellino, Via Val Platani 3, I-90144 Palermo, Italy GF Ingrassia Hosp Via Val Platani 3 Palermo Italy I-90144
Citazione:
P. Di Pasquale et al., "ACE-inhibition plus mineralocorticoid antagonism versus ACE-inhibition alone in patients with anterior myocardial infarction", CARDIO DRUG, 15(4), 2001, pp. 309-314

Abstract

Background. Aldosterone exerts pro-fibrotic effects, acting via mineralo-corticoid reeptors in cardiovascular tissues. Aldosterone antagonism in combination with ACE inhibition may better protect against untoward effects of aldosterone than ACE inhibition alone. Methods. In a double blind, randomised study the tolerability and efficacyof canreonate (25 mg/day) plus captopril versus captopril alone were evaluated in 187 patients with an acute anterior myocardial infarction (MI) and a serum creatinine concentration <2.0 mg/dL and a serum K concentration <5.0 mmol/L. Ninety-four patients received captopril and 25 mg canreonate (group A). Group B (93 patients) received captopril and placebo. At baseline and at 10 and 90 days after admission Doppler echocardiography was performed. Results. Clinical and demographic aspects were similar in both groups. Also, baseline cardiac enzyme levels, left ventricular (LV) function and incidence of surgical interventions and angioplasty were comparable. Overall, creatinine, blood urea and serum K did not show significant differences between groups. However, in 9 patients in group A increases in serum K > 5.5 mmol/dL and creatinine >2.0 mg/L were observed after 10 days of treatment. At 90 days, the mitral E/A ratio was higher (p = 0.001) and LV end systolic volume smaller (p = 0.021) in patients treated with canreonate than in those receiving placebo. No further side effects were observed during the study period. Conclusions. Our data suggest that the combination of captopril plus canreonate is well tolerated following an acute myocardial infarction and has a beneficial effect on diastolic and systolic LV parameters and may decrease post-MI remodelling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 07:44:59