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Titolo:
Association of aflatoxin B-1-albumin adduct levels with hepatitis B surface antigen status among adolescents in Taiwan
Autore:
Chen, SY; Chen, CJ; Chou, SR; Hsieh, LL; Wang, LY; Tsai, WY; Ahsan, H; Santella, RM;
Indirizzi:
Columbia Univ, Mailman Sch Publ Hlth, Dept Environm Hlth Sci, New York, NY10032 USA Columbia Univ New York NY USA 10032 ironm Hlth Sci, New York, NY10032 USA Columbia Univ, Mailman Sch Publ Hlth, Dept Biostat, New York, NY 10032 USAColumbia Univ New York NY USA 10032 Dept Biostat, New York, NY 10032 USA Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10032 USA Columbia Univ New York NY USA 10032 ept Epidemiol, New York, NY 10032 USA Natl Taiwan Univ, Coll Publ Hlth, Grad Inst Epidemiol, Taipei 10018, Taiwan Natl Taiwan Univ Taipei Taiwan 10018 nst Epidemiol, Taipei 10018, Taiwan Chang Gung Univ, Dept Publ Hlth, Taoyuan, Taiwan Chang Gung Univ TaoyuanTaiwan ng Univ, Dept Publ Hlth, Taoyuan, Taiwan Acad Sinica, Inst Biomed Sci, Taipei 11529, Taiwan Acad Sinica Taipei Taiwan 11529 a, Inst Biomed Sci, Taipei 11529, Taiwan
Titolo Testata:
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
fascicolo: 11, volume: 10, anno: 2001,
pagine: 1223 - 1226
SICI:
1055-9965(200111)10:11<1223:AOABAL>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
REPUBLIC-OF-CHINA; HEPATOCELLULAR-CARCINOMA; VIRUS-INFECTION; CHEMICAL HEPATOCARCINOGENS; METABOLIC-ACTIVATION; TRANSGENIC MICE; ALBUMIN ADDUCTS; INCREASED RISK; B-1; LIVER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Santella, RM Columbia Univ, Mailman Sch Publ Hlth, Dept Environm Hlth Sci,Room 505,701W 168th St, New York, NY 10032 USA Columbia Univ Room 505,701 W 168th St New York NY USA 10032 A
Citazione:
S.Y. Chen et al., "Association of aflatoxin B-1-albumin adduct levels with hepatitis B surface antigen status among adolescents in Taiwan", CANC EPID B, 10(11), 2001, pp. 1223-1226

Abstract

Chronic hepatitis B virus (HBV) infection and aflatoxin B-1 (AFB(1)) exposure interact synergetically to induce hepatocellular carcinoma. One suggested mechanism for this interaction is the enhanced activation of AFB(1) in chronically HBV-infected individuals. Whereas no associations between chronic HBV infection and AFB(1)-albumin adducts were observed in several studiesin adults, hepatitis B surface antigen (HbsAg)-positive children were found to have elevated adducts in Gambia. To assess the association between chronic HBV infection and AFB(1)-albumin adduct level in Taiwan, 200 junior high school adolescents from 20 townships were assayed for HBsAg and AFB(1)-albumin adducts. The mean AFB(1)-albumin adduct level was higher in HBsAg-positive compared with HBsAg-negative subjects. The association between HBsAgstatus and AFB(1)-albumin adducts remained after multivariate adjustment. This finding additionally supports the synergetic interaction between HBV and AFB(1), but the mechanism remains to be elucidated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:48:35