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Titolo:
Oral squamous cell cancer risk in relation to alcohol consumption and alcohol dehydrogenase-3 genotypes
Autore:
Schwartz, SM; Doody, DR; Fitzgibbons, ED; Ricks, S; Porter, PL; Chen, C;
Indirizzi:
Fred Hutchinson Canc Res Ctr, Program Epidemiol, Div Publ Hlth Sci, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98109 , Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Program Canc Biol, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98109 , Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr, Div Human Biol, Program Canc Biol, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98109 , Seattle, WA 98109 USA Univ Washington, Sch Publ Hlth & Community Med, Dept Epidemiol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Epidemiol, Seattle, WA 98195 USA Univ Washington, Sch Med, Dept Pathol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 , Dept Pathol, Seattle, WA 98195 USA Univ Washington, Sch Med, Dept Otolaryngol Head & Neck Surg, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 d & Neck Surg, Seattle, WA 98195 USA
Titolo Testata:
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
fascicolo: 11, volume: 10, anno: 2001,
pagine: 1137 - 1144
SICI:
1055-9965(200111)10:11<1137:OSCCRI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
UPPER AERODIGESTIVE TRACT; ACETALDEHYDE PRODUCTION; GENETIC-POLYMORPHISM; CAVITY CANCER; ALCOHOL-DEHYDROGENASE-3; TUMORS; ADH; SUSCEPTIBILITY; NOMENCLATURE; LEUKOPLAKIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Schwartz, SM Fred Hutchinson Canc Res Ctr, Program Epidemiol, Div Publ Hlth Sci, 1100 Fairview Ave N,MP-381,POB 19024, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr 1100 Fairview Ave N,MP-381,POB 19024 Seattle WA USA 98109
Citazione:
S.M. Schwartz et al., "Oral squamous cell cancer risk in relation to alcohol consumption and alcohol dehydrogenase-3 genotypes", CANC EPID B, 10(11), 2001, pp. 1137-1144

Abstract

Heavy alcohol consumption, particularly in combination with cigarette smoking, increases the risk of oral squamous cell carcinoma (OSCC). Alcohol dehydrogenase 3 (ADH3) converts ethanol to acetaldehyde, which is a suspected oral carcinogen. The ADH3*1 allele is associated with increased conversion of ethanol to acetaldehyde, but whether the risk of OSCC is increased amongADH3*1 carriers, or whether the risk of OSCC attributable to alcohol consumption is modified by ADH3 genotype is unclear from previous studies. We examined the association between ADH3 genotypes, alcohol consumption, and OSCC risk in a population-based study of 333 cases and 541 controls from the state of Washington. The distribution of ADH3 genotypes was similar among cases and controls: ADH3*1/*1: 32.7% cases, 36.5% controls; ADH3*1/*2: 49.0% cases, 43.1% controls: ADH3*2/*2: 18.3% cases, 20.3% controls. The age-, sex-, and race-adjusted odds ratios (OR), relative to ADH3*2/*2 carriers, were as follows: ADH*1/*1: OR, 1.0 [95% confidence interval (CI) = 0.7, 1.5]; and ADH3*1/*2: OR, 1.3 (95% Cl = 1.0, 1.8). We modeled the risk of OSCC associated with alcohol consumption as modified by ADH3 genotype adjusting forage, sex, race, and cigarette smoking. Among ADH3*2 homozygotes, the risk of OSCC increased 5.3% (2.1-8.5%) with each additional alcoholic drink/week, compared with 2.5% (1.5-2.6%) and 1.2% (0.0-2.4%) among persons carrying the ADH3*1/*2 and ADH3*1/*1 genotypes, respectively. These data suggest that the ADH3*2 allele confers increased susceptibility to the effect of alcohol on OSCC risk in our population.

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Documento generato il 01/04/20 alle ore 02:22:21