Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
HIV-1 receptors and cell tropism
Autore:
Clapham, PR; McKnight, A;
Indirizzi:
Univ Massachusetts, Sch Med, Dept Mol Genet & Microbiol, Program Mol Med,Ctr AIDS Res, Worcester, MA 01605 USA Univ Massachusetts Worcester MA USA 01605 DS Res, Worcester, MA 01605 USA Univ Coll London, Windeyer Inst Med Sci, Dept Immunol & Mol Pathol, Wohl Vir Ctr, London, England Univ Coll London London England l Pathol, Wohl Vir Ctr, London, England
Titolo Testata:
BRITISH MEDICAL BULLETIN
, volume: 58, anno: 2001,
pagine: 43 - 59
SICI:
0007-1420(2001)58:<43:HRACT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; RECOMBINANT SOLUBLE CD4; AIDS-RELATED COMPLEX; GP120 ENVELOPE GLYCOPROTEIN; SMALL-MOLECULE INHIBITOR; CHEMOKINE RECEPTOR; T-CELLS; PERIPHERAL-BLOOD; DENDRITIC CELLS; TYPE-1 ENTRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
89
Recensione:
Indirizzi per estratti:
Indirizzo: Clapham, PR Univ Massachusetts, Sch Med, Dept Mol Genet & Microbiol, Program Mol Med,Ctr AIDS Res, 373 Plantat St, Worcester, MA 01605 USA Univ Massachusetts 373 Plantat St Worcester MA USA 01605 5 USA
Citazione:
P.R. Clapham e A. McKnight, "HIV-1 receptors and cell tropism", BR MED B, 58, 2001, pp. 43-59

Abstract

HIV virus particles interact with Several receptors on cell surfaces. Two receptors, CD4 and a co-receptor act sequentially to trigger fusion of viral and cellular membranes and confer virus entry into cells. For HIV-1, the chemokine receptor CCR5 is the predominant co-receptor exploited for transmission and replication in vivo. Variants that switch to use CXCR4 and perhaps other co-receptors evolve in some infected individuals and have altered tropism and pathogenic properties. Other cell surface receptors including mannose binding protein on macrophages and DC-SIGN on dendritic cells also interact with gp120 on virus particles but do not actively promote fusion and virus entry. These receptors may tether virus particles to cells enablinginteractions with suboptimal concentrations of CD4 and/or co-receptors. Alternatively such receptors may transport cell surface trapped virions into lymph nodes before transmitting them to susceptible cells. Therapeutic strategies that prevent HIV from interacting with receptors are currently beingdeveloped. This review describes how the interaction and use of different cellular receptors influences HIV tropism and pathogenesis in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:58:37