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Titolo:
Release of non-neuronal acetylcholine from the isolated human placenta is mediated by organic cation transporters
Autore:
Wessler, I; Roth, E; Deutsch, C; Brockerhoff, P; Bittinger, F; Kirkpatrick, CJ; Kilbinger, H;
Indirizzi:
Univ Mainz, Dept Pharmacol, D-55101 Mainz, Germany Univ Mainz Mainz Germany D-55101 Dept Pharmacol, D-55101 Mainz, Germany Univ Mainz, Inst Pathol, D-55101 Mainz, Germany Univ Mainz Mainz GermanyD-55101 nz, Inst Pathol, D-55101 Mainz, Germany Univ Mainz, Clin Obstet, D-55101 Mainz, Germany Univ Mainz Mainz GermanyD-55101 nz, Clin Obstet, D-55101 Mainz, Germany
Titolo Testata:
BRITISH JOURNAL OF PHARMACOLOGY
fascicolo: 5, volume: 134, anno: 2001,
pagine: 951 - 956
SICI:
0007-1188(200111)134:5<951:RONAFT>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONNEURONAL ACETYLCHOLINE; FUNCTIONAL EXPRESSION; CHOLINERGIC SYSTEM; BIOLOGICAL-SYSTEMS; RAT; RECEPTORS; MOLECULE; CELLS; LYMPHOCYTES; CLONING;
Keywords:
human placenta; non-neuronal acetylcholine; organic cation transporter; quinine; corticosterone; anti-sense oligonucleotides;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Wessler, I Univ Mainz, Dept Pharmacol, Obere Zahlbacher Str 67, D-55101 Mainz, Germany Univ Mainz Obere Zahlbacher Str 67 Mainz Germany D-55101 rmany
Citazione:
I. Wessler et al., "Release of non-neuronal acetylcholine from the isolated human placenta is mediated by organic cation transporters", BR J PHARM, 134(5), 2001, pp. 951-956

Abstract

1 The release of acetylcholine was investigated in the human placenta villus, a useful model for the characterization of the non-neuronal cholinergicsystem.2 Quinine, an inhibitor of organic cation transporters (OCT), reduced acetylcholine release in a reversible and concentration-dependent manner with an IC50 value of 5 muM. The maximal effect, inhibition by 99%, occurred at aconcentration of 300 um.3 Procaine (100 muM), a sodium channel blocker, and vesamicol (10 muM), aninhibitor of the vesicular acetylcholine transporter, were ineffective.4 Corticosterone, an inhibitor of OCT subtype 1, 2 and 3 reduced acetylcholine in a concentration-dependent manner with an IC50 value of 2 muM.5 Substrates of OCT subtype 1, 2 and 3 (amiloride, cimetidine, guanidine, noradrenaline, verapamil) inhibited acetylcholine release, whereas carnitine, a substrate of subtype OCTN2, exerted no effect,6 Long term exposure (48 and 72 h) of villus strips to anti-sense oligonucleotides (5 muM) directed against transcription of OCT1 and OCT3 reduced the release of acetylcholine, whereas OCT2 antisense oliogonucleotides were ineffective.7 It is concluded that the release of non-neuronal acetylcholine from the human placenta is mediated via organic cation transporters of the OCT1 and OCT3 subtype.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 13:39:01