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Titolo:
Age- and genotype-dependence of bone material properties in the osteogenesis imperfecta murine model (oim)
Autore:
Grabner, B; Landis, WJ; Roschger, P; Rinnerthaler, S; Peterlik, H; Klaushofer, K; Fratzl, P;
Indirizzi:
Osterreichischen Akad Wissensch, Erich Schmid Inst, A-8700 Leoben, AustriaOsterreichischen Akad Wissensch Leoben Austria A-8700 00 Leoben, Austria Univ Min & Met Leoben, A-8700 Leoben, Austria Univ Min & Met Leoben Leoben Austria A-8700 oben, A-8700 Leoben, Austria Hanusch Hosp, Dept Med 4, Ludwig Boltzmann Inst Osteol, Vienna, Austria Hanusch Hosp Vienna Austria dwig Boltzmann Inst Osteol, Vienna, Austria UKH Meidling, Vienna, Austria UKH Meidling Vienna AustriaUKH Meidling, Vienna, Austria Northeastern Ohio Univ, Coll Med, Rootstown, OH USA Northeastern Ohio Univ Rootstown OH USA niv, Coll Med, Rootstown, OH USA Univ Vienna, Mat Phys Inst, Vienna, Austria Univ Vienna Vienna AustriaUniv Vienna, Mat Phys Inst, Vienna, Austria
Titolo Testata:
BONE
fascicolo: 5, volume: 29, anno: 2001,
pagine: 453 - 457
SICI:
8756-3282(200111)29:5<453:AAGOBM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
X-RAY-SCATTERING; MINERAL CRYSTALS; MECHANICAL-PROPERTIES; ELECTRON-MICROSCOPY; CALCIFIED TISSUES; MICE EXHIBIT; COLLAGEN; DENSITY; TENDON; CHILDREN;
Keywords:
osteogenesis imperfecta (OI); murine model, small-angle X-ray scattering (SAXS); quantitative backscattered electron imaging (qBEI), mineral density distribution; microhardness;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Fratzl, P Osterreichischen Akad Wissensch, Erich Schmid Inst, Jahnstr 12, A-8700 Leoben, Austria Osterreichischen Akad Wissensch Jahnstr 12 Leoben Austria A-8700
Citazione:
B. Grabner et al., "Age- and genotype-dependence of bone material properties in the osteogenesis imperfecta murine model (oim)", BONE, 29(5), 2001, pp. 453-457

Abstract

Cortical mineralization of long bones was studied in collagen alpha2(I)-deficient mice (oim) used as a model for human osteogenesis imperfecta. Aspects of the age development of the mice were characterized by combining nanometer- to micrometer-scale structural analysis with microhardness measurements. Bone structure was determined from homozygous (oini/oim) and heterozygous (oim/+) mice and their normal (+/+) littermates as a function of animal age by small-angle X-ray scattering (SAXS) and quantitative backscattered electron imaging (qBEI) measurements. SAXS studies found anomalies in the size and arrangement of bone mineral crystals in both homozygous and heterozygous mice aged 1-14 months. Generally, the crystals were smaller in thickness and less well aligned in these mice compared with control animals. An increase in the mean crystal thickness of the bone was found within all threegenotypes up to an age of 3 months. Vicker's hardness measurements were significantly enhanced for oim bone (homozygotes and heterozygotes) compared with controls. The microhardness values were correlated directly with increased mineral content of homozygous and heterozygous compared with control bone, as determined by qBEI analysis. There was also a significant increase of mineral content with age. Two possibilities for collagen-mineral association are discussed for explaining the increased hardness and mineral content of oim/oim bone, together with its decreased toughness and thinner mineral crystals. As a consequence of the present measurements, one model for oimbone could incorporate small and densely packed mineral crystals. A secondmodel for possible collagen-mineral association in oim material would consist of two families of mineral crystals, one being smaller and the other being much larger than the crystals found in normal mouse long bones. (C) 2001 by Elsevier

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Documento generato il 19/09/20 alle ore 15:12:05