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Titolo:
Efficacy of low-intensity pulsed ultrasound in the prevention of osteoporosis following spinal cord injury
Autore:
Warden, SJ; Bennell, KL; Matthews, B; Brown, DJ; McMeeken, JM; Wark, JD;
Indirizzi:
Univ Melbourne, Sch Physiotherapy, Ctr Sports Med Res & Educ, Parkville, Vic 3010, Australia Univ Melbourne Parkville Vic Australia 3010 arkville, Vic 3010, Australia Austin & Repatriat Med Ctr, Victorian Spinal Cord Serv, Heidelberg, Vic, Australia Austin & Repatriat Med Ctr Heidelberg Vic Australia berg, Vic, Australia Univ Melbourne, Dept Med, Parkville, Vic 3052, Australia Univ Melbourne Parkville Vic Australia 3052 arkville, Vic 3052, Australia Royal Melbourne Hosp, Bone & Mineral Serv, Parkville, Vic 3050, Australia Royal Melbourne Hosp Parkville Vic Australia 3050 le, Vic 3050, Australia
Titolo Testata:
BONE
fascicolo: 5, volume: 29, anno: 2001,
pagine: 431 - 436
SICI:
8756-3282(200111)29:5<431:EOLPUI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MINERAL DENSITY; LOWER-EXTREMITIES; ACCELERATION; STIMULATION; INDUCTION; FRACTURES;
Keywords:
bone; dual-energy X-ray absorptiometry (DXA); fracture; osteoporosis; quantitative ultrasound (qUS); ultrasound;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Bennell, KL Univ Melbourne, Sch Physiotherapy, Ctr Sports Med Res & Educ, Parkville, Vic 3010, Australia Univ Melbourne Parkville Vic Australia 3010c 3010, Australia
Citazione:
S.J. Warden et al., "Efficacy of low-intensity pulsed ultrasound in the prevention of osteoporosis following spinal cord injury", BONE, 29(5), 2001, pp. 431-436

Abstract

Ultrasound (US), a high-frequency acoustic energy traveling in the form ofa mechanical wave, represents a potential site-specific intervention for osteoporosis. Bone is a dynamic tissue that remodels in response to applied mechanical stimuli. As a form of mechanical stimulation, US is anticipated to produce a similar remodeling response. This theory is supported by growing in vitro and in vivo evidence demonstrating an osteogenic effect of pulsed-wave US at low spatial-averaged temporal-averaged intensities. The aim of this study was to investigate whether low-intensity pulsed US could prevent calcaneal osteoporosis in individuals following spinal cord injury (SCI). Fifteen patients with a 1-6 month history of SCI were recruited. Active US was introduced to one heel for 20 min/day, 5 days/week, over 6 weeks. Thecontralateral heel was simultaneously treated with inactive US. Patients were blind to which heel was being actively treated. Active US pulsed with a10 mu sec burst of 1.0 MHz sine waves repeating at 3.3 kHz. The spatial-averaged temporal-averaged intensity was set at 30 MW/cm(2). Bone status was assessed at baseline and following the intervention period by dual-energy X-ray absorptiometry and quantitative US. SCI resulted in significant bone loss. Bone mineral content decreased by 7.5 +/- 3.0% in inactive US-treated caleanei (p < 0.001). Broadband US attenuation and speed of sound decreasedby 8.5 +/- 6.9% (p < 0.001) and 1.5 +/- 1.3% (p < 0.001), respectively. There were no differences between active and inactive US-treated calcanei forany skeletal measure (p <greater than> 0.05). These findings confirm the negative skeletal impact of SCI, and demonstrate that US at the dose and mode administered was not a beneficial intervention for SCI-Induced osteoporosis. This latter finding may primarily relate to the inability of US to effectively penetrate the outer cortex of bone due to its acoustic properties. (C) 2001 by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 01:08:05