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Titolo:
Seeking genetic causes of "osteoporosis": Insights of the utah paradigm ofskeletal physiology
Autore:
Frost, HM;
Indirizzi:
So Colorado Clin, Dept Orthoped Surg, Pueblo, CO 81008 USA So Colorado Clin Pueblo CO USA 81008 Orthoped Surg, Pueblo, CO 81008 USA
Titolo Testata:
BONE
fascicolo: 5, volume: 29, anno: 2001,
pagine: 407 - 412
SICI:
8756-3282(200111)29:5<407:SGCO"I>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSCLE STRENGTH; BONE STRENGTH; ESTROGEN; MASS; POLYMORPHISMS; FRACTURES; DENSITY; MODEL; RISK; AGE;
Keywords:
genes; bone strength; modeling; remodeling; biomechanics; absorptiometry; pathogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Frost, HM So Colorado Clin, Dept Orthoped Surg, POB 9000, Pueblo, CO 81008USA So Colorado Clin POB 9000 Pueblo CO USA 81008 eblo, CO 81008 USA
Citazione:
H.M. Frost, "Seeking genetic causes of "osteoporosis": Insights of the utah paradigm ofskeletal physiology", BONE, 29(5), 2001, pp. 407-412

Abstract

This article investigates: (1) the criteria used to select cohorts of patients for study when seeking genetic causes of "osteoporosis;" (2) the possibilities, genetic and otherwise, that might cause or help to cause this disorder; and (3) how one should define this disorder and bone health. Patients selected for such a study because current World Health Organization (WHO)absorptiometric criteria diagnosed them with "osteoporosis," or because they had extremity bone fractures, could possibly include people with biologically different disorders, in addition to those with healthy or diseased bones. Seeking a common genetic cause of "osteoporosis" in such inhomogeneouscohorts may be like seeking a common genetic cause of "anemia" in a cohortthat contained iron deficiency and pernicious anemias, thalassemia, sickle-cell disease, anemias due to blood loss, malnutrition, malaria, metastaticdisease, etc. The Utah paradigm's insights suggest how to select more homogeneous cohorts for such studies. This would require defining bone health in a way that acknowledges the main purpose of load-bearing bones, which theWHO criteria do not do. The present understanding of bone physiology indicates that many biologic mechanisms and features could cause or help to cause an osteopenia or osteoporosis. This study identifies 30 such mechanisms, some osseous and some extraosseous, and even this number seems conservative. Because each such mechanism could depend on any number of genes, when a strong genetic association with some kind of osteopenia or osteoporosis is found it could be difficult to determine which mechanism(s) it perturbed. This article summarizes the evidence and ideas on which these suggestions depend. (C) 2001 by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 05:44:58