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Titolo:
Role of the sarcoplasmic reticulum Ca2+-ATPase on heat production and thermogenesis
Autore:
de Meis, L;
Indirizzi:
Univ Fed Rio de Janeiro, Inst Ciencias Biomed, Dept Bioquim Med, BR-21941590 Rio De Janeiro, Brazil Univ Fed Rio de Janeiro Rio De Janeiro Brazil BR-21941590 BCeiro, Brazil
Titolo Testata:
BIOSCIENCE REPORTS
fascicolo: 2, volume: 21, anno: 2001,
pagine: 113 - 137
SICI:
0144-8463(200104)21:2<113:ROTSRC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CA2+ TRANSPORT ATPASES; CALCIUM-PUMP; ATP SYNTHESIS; TRANSMEMBRANE CHANNEL; UNCOUPLING PROTEIN-3; PHOSPHATE-COMPOUNDS; BLOOD-PLATELETS; THYROID-HORMONE; ENERGY; MUSCLE;
Keywords:
Ca2+-ATPase; Ca2+ transport; energy interconversion; ATP hydrolysis; heat production; sarcoplasmic reticulum;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: de Meis, L Univ Fed Rio de Janeiro, Inst Ciencias Biomed, Dept Bioquim Med, Cidade Univ, BR-21941590 Rio De Janeiro, Brazil Univ Fed Rio de Janeiro Cidade Univ Rio De Janeiro Brazil BR-21941590 BC
Citazione:
L. de Meis, "Role of the sarcoplasmic reticulum Ca2+-ATPase on heat production and thermogenesis", BIOSCI REP, 21(2), 2001, pp. 113-137

Abstract

The sarcoplasmic reticulum of skeletal muscle retains a membrane bound Ca2-ATPase which is able to interconvert different forms of energy. A part ofthe chemical energy released during ATP hydrolysis is converted into heat and in the bibliography it is assumed that the amount of heat produced during the hydrolysis of an ATP molecule is always the same, as if the energy released during ATP cleavage were divided in two non-interchangeable parts: one would be converted into heat, and the other used for Ca2+ transport. Data obtained in our laboratory during the past three years indicate that theamount of heat released during the hydrolysis of ATP may vary between 7 and 32 kcal/mol depending on whether or not a transmembrane Ca2+ gradient is formed across the sarcoplasmic reticulum membrane. Drugs such as heparin and dimethyl sulfoxide are able to modify the fraction of the chemical energyreleased during ATP hydrolysis which is used for Ca2+ transport and the fraction which is dissipated in the surrounding medium as heat.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:45:35