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Titolo:
6-(4-benzylpiperazin-1-yl)benzodioxanes as selective ligands at cloned primate dopamine D-4 receptors
Autore:
Hodgetts, KJ; Kieltyka, A; Brodbeck, R; Tran, JN; Wasley, JWF; Thurkauf, A;
Indirizzi:
Neurogen Corp, Branford, CT 06405 USA Neurogen Corp Branford CT USA 06405Neurogen Corp, Branford, CT 06405 USA
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY
fascicolo: 12, volume: 9, anno: 2001,
pagine: 3207 - 3213
SICI:
0968-0896(200112)9:12<3207:6ASLAC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-AFFINITY; ANTAGONIST; D4; NEUROLEPTICS; CLOZAPINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Hodgetts, KJ Neurogen Corp, 35 NE Ind Rd, Branford, CT 06405 USA Neurogen Corp 35 NE Ind Rd Branford CT USA 06405 CT 06405 USA
Citazione:
K.J. Hodgetts et al., "6-(4-benzylpiperazin-1-yl)benzodioxanes as selective ligands at cloned primate dopamine D-4 receptors", BIO MED CH, 9(12), 2001, pp. 3207-3213

Abstract

A series of novel 6-(4-benzylpiperazin-1-yl)benzodioxanes were prepared and screened at selected dopamine receptor subtypes. 6-(4-[4-Chlorobenzyl]piperazin-1-yl)benzodioxane (2d) had high affinity and selectivity for the D-4dopamine receptor subtype and was identified as a D-4 antagonist via its attenuation of dopamine-induced GT gamma S-35 binding at the D-4 receptor. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 07:05:46