Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Down-regulation and recovery of endothelin-1 binding and signaling in rat cardiomyocytes
Autore:
Harvey, SAK; Gandhi, CR; Behal, RH; Olson, MS;
Indirizzi:
Univ Texas, Hlth Sci Ctr, Dept Biochem, San Antonio, TX 78284 USA Univ Texas San Antonio TX USA 78284 pt Biochem, San Antonio, TX 78284 USA
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 3, volume: 288, anno: 2001,
pagine: 558 - 563
SICI:
0006-291X(20011102)288:3<558:DAROEB>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; VASOCONSTRICTOR PEPTIDE; I-125 ENDOTHELIN-1; RECEPTOR; HYPERTROPHY; PLASMA; ASSOCIATION; HYDROLYSIS; EXPRESSION; MECHANISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Harvey, SAK Univ Pittsburgh, Med Ctr, Dept Ophthalmol, 203 Lothrop St, Pittsburgh, PA 15213 USA Univ Pittsburgh 203 Lothrop St Pittsburgh PA USA 15213 213 USA
Citazione:
S.A.K. Harvey et al., "Down-regulation and recovery of endothelin-1 binding and signaling in rat cardiomyocytes", BIOC BIOP R, 288(3), 2001, pp. 558-563

Abstract

Down-regulation and recovery of endothelin (ET) receptors and of ET-dependent phosphoinositide-specific phospholipase C (PI-PLC) signaling was examined in cultured cardiomyocytes from neonatal rats. Three hours treatment with 5 nM ET-1 decreased surface receptors to 30%, and transduction to 19%, oftheir respective time-zero values. After extensive washing and a 3 h recovery period surface receptors returned to 74% of the time-zero value, with concomitant recovery of signal transduction to 75% of the time-zero value. The recovery of PI-PLC signaling in these cells is in contrast with a previous report, but consistent with recovery of the receptor complement. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 00:18:02