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Titolo:
BARORECEPTOR-INDEPENDENT RENAL NERVE INHIBITION BY INTRACEREBROVENTRICULAR ANGIOTENSIN-II IN CONSCIOUS SHEEP
Autore:
MAY CN; MCALLEN RM;
Indirizzi:
UNIV MELBOURNE,HOWARD FLOREY INST EXPT PHYSIOL & MED PARKVILLE VIC 3052 AUSTRALIA
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 2, volume: 42, anno: 1997,
pagine: 560 - 567
SICI:
0363-6119(1997)42:2<560:BRNIBI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRALLY-ADMINISTERED ANGIOTENSIN; PLASMA-RENIN ACTIVITY; BLOOD-PRESSURE; VASOPRESSIN; RESPONSES; BAROREFLEX; ARTERIAL; RABBITS; SODIUM; SYSTEM;
Keywords:
ARTERIAL BARORECEPTORS; CARDIOPULMONARY RECEPTORS; CENTRAL VENOUS PRESSURE; LOSARTAN; RENIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
C.N. May e R.M. Mcallen, "BARORECEPTOR-INDEPENDENT RENAL NERVE INHIBITION BY INTRACEREBROVENTRICULAR ANGIOTENSIN-II IN CONSCIOUS SHEEP", American journal of physiology. Regulatory, integrative and comparative physiology, 42(2), 1997, pp. 560-567

Abstract

The effect of central administration of angiotensin II (ANG II) on efferent renal sympathetic nerve activity (RSNA) was studied in conscious sheep. ANG II (1 nmol/h), infused for 30 min into the lateral cerebral ventricles in five sheep, did not alter mean arterial. pressure (MAP) but reduced RSNA to 38 +/- 5% of control. Intracerebroventricular infusion of higher doses of ANG II (3 and 10 nmol/h), which increased MAP by 12 +/- 2 and 14 +/- 3 mmHg, respectively, reduced RSNA to 9 +/- 5 and 11 +/- 7% of control. MAP and RSNA gradually returned to controlover a period of 2 h after the infusions. Intracerebroventricular losartan (1 mg/h for 1 h before, and then during, angiotensin infusion) blocked all. the effects of angiotensin (3 nmol/h). Baroreflex relationships constructed from the beat-to-beat relationship of RSNA to diastolic pressure showed a significant leftward shift during intracerebroventricular ANG II compared with the control relationship. The beat-to-beat relationship between central venous pressure and RSNA was abolished during intracerebroventricular infusion of ANG II. These findings demonstrate that intracerebroventricular ANG II has a direct central inhibitory action on RSNA that is independent of both arterial and low-pressure baroreceptors. This effect of angiotensin is mediated by central angiotensin AT-1 receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 09:56:46