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Titolo:
Development of infection resistant polyurethane biomaterials using textiledyeing technology
Autore:
Phaneuf, MD; Bide, MJ; Szycher, M; Gale, MB; Huang, HX; Yang, CQ; LoGerfo, FW; Quist, WC;
Indirizzi:
Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA Beth Israel Deaconess Med Ctr Boston MA USA 02115 r, Boston, MA 02115 USA Univ Rhode Isl, Dept Text, Kingston, RI USA Univ Rhode Isl Kingston RI USA iv Rhode Isl, Dept Text, Kingston, RI USA Cardiotech Int Inc, Woburn, MA USA Cardiotech Int Inc Woburn MA USACardiotech Int Inc, Woburn, MA USA
Titolo Testata:
ASAIO JOURNAL
fascicolo: 6, volume: 47, anno: 2001,
pagine: 634 - 640
SICI:
1058-2916(200111/12)47:6<634:DOIRPB>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR PROSTHETIC INFECTION; GRAFT INFECTION; DRUG DELIVERY; DACRON GRAFT; PREVENTION; PROTECTION; SURFACE; POLYTETRAFLUOROETHYLENE; PROPHYLAXIS; ADHESION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Phaneuf, MD Beth Israel Deaconess Med Ctr, 4 Blackfan Circle,Room 131, Boston, MA 02115 USA Beth Israel Deaconess Med Ctr 4 Blackfan Circle,Room 131 Boston MA USA 02115
Citazione:
M.D. Phaneuf et al., "Development of infection resistant polyurethane biomaterials using textiledyeing technology", ASAIO J, 47(6), 2001, pp. 634-640

Abstract

Infection is a major complication when using biomaterials such as polyurethane in the clinical setting. The purpose of this study was to develop a novel infection resistant polyurethane biomaterial using textile dyeing technology. This procedure results in incorporation of the antibiotic into the polymer, resulting in a slow, sustained release of antibiotic from the material over time, without the use of exogenous binder agents. Polycarbonate based urethanes were synthesized that contained either a non-ionic (bdPU) or anionic (cPU) chain extender within the polymer backbone and cast into films. The fluoroquinolone antibiotic ciprofloxacin (Cipro) was applied to bdPUand cPU using textile dyeing technology, with Cipro uptake determined by absorbance reduction of the "dyebath. " These dyed bdPU/cPU samples were thenevaluated for prolonged Cipro release and antimicrobial activity by means of spectrophotometric and zone of inhibition assays, respectively. Cipro release and antimicrobial activity by dyed cPU segments that were aggressively washed persisted over 9 days, compared with dyed bdPU and dipped cPU control segments that lasted < 24 hours. Dyed cPU segments, which remained in astatic wash solution, maintained antimicrobial activity for 11 days (length of study), whereas controls again lost antimicrobial activity within 24 hours. Thus, application of Cipro to the cPU polymer by means of dyeing technology results in a slow sustained release of antibiotic with persistent bacteriocidal properties over extended periods of time.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 14:30:23