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Titolo:
Tegumental alterations in Schistosoma mansoni worms induced by treatment of infected mice with naproxen pre- and/or post-infection
Autore:
Hassan, S; Mohamed, S; Sabry, H;
Indirizzi:
Theodor Bilharz Res Inst, Dept Parasitol, Giza, Egypt Theodor Bilharz Res Inst Giza Egypt s Inst, Dept Parasitol, Giza, Egypt Ain Shams Univ, Fac Sci, Dept Zool, Cairo, Egypt Ain Shams Univ Cairo Egypt Shams Univ, Fac Sci, Dept Zool, Cairo, Egypt
Titolo Testata:
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
fascicolo: 10, volume: 51, anno: 2001,
pagine: 843 - 847
SICI:
0004-4172(2001)51:10<843:TAISMW>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MURINE SCHISTOSOMIASIS; PENETRATION; PROSTAGLANDINS; PRAZIQUANTEL; IBUPROFEN;
Keywords:
anti-inflammatories, non-steroidal; CAS 22204-53-1; naproxen, change of S. mansoni tegument; Schistosoma mansoni;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Sabry, H Theodor Bilharz Res Inst, Dept Parasitol, POB 30, Giza, Egypt Theodor Bilharz Res Inst POB 30 Giza Egypt POB 30, Giza, Egypt
Citazione:
S. Hassan et al., "Tegumental alterations in Schistosoma mansoni worms induced by treatment of infected mice with naproxen pre- and/or post-infection", ARZNEI-FOR, 51(10), 2001, pp. 843-847

Abstract

Schistosoma mansoni infected mice were treated with naproxen (CAS 22204-53-1) in a dose of 3-4 mg/kg body weight. Treatment was conducted for 7 days before and/or 28 days post infection. Adult worms, developed 7 weeks post infection, were studied by electron microscopy. in both groups, the dorsal surface of the male worms was much more affected by the drug than that of female ones. The most significant morphological degeneration was the change in the aspect and the form of tubercles. Moreover, shrinkage and loss of spines from the ventral surface were also observed. A small portion of the posterior end of female worms showed loss of spines. However, in the first group given naproxen 7 days before infection, the level and extent of changes increased particularly in male worms. There was pronounced oedema, swelling, wrinkling with constriction and collapse of sensory bulbs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 10:34:00