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Titolo:
Genetic control of coordinated changes in HDL and LDL size phenotypes
Autore:
Rainwater, DL; Martin, LJ; Comuzzie, AG;
Indirizzi:
SW Fdn Biomed Res, Dept Genet, San Antonio, TX 78245 USA SW Fdn Biomed Res San Antonio TX USA 78245 net, San Antonio, TX 78245 USA
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 11, volume: 21, anno: 2001,
pagine: 1829 - 1833
SICI:
1079-5642(200111)21:11<1829:GCOCCI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; CORONARY-ARTERY DISEASE; HEPATIC LIPASE ACTIVITY; REVERSE CHOLESTEROL TRANSPORT; GRADIENT GEL-ELECTROPHORESIS; ISCHEMIC-HEART-DISEASE; MYOCARDIAL-INFARCTION; HYPERTRIGLYCERIDEMIC PLASMA; TRANSFER PROTEINS; PARTICLE-SIZE;
Keywords:
LDL size distributions; HDL size distributions; genetics; triglycerides; Mexican Americans;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Rainwater, DL SW Fdn Biomed Res, Dept Genet, POB 760549, San Antonio, TX 78245 USA SW Fdn Biomed Res POB 760549 San Antonio TX USA 78245 45 USA
Citazione:
D.L. Rainwater et al., "Genetic control of coordinated changes in HDL and LDL size phenotypes", ART THROM V, 21(11), 2001, pp. 1829-1833

Abstract

We investigated the correlation of high density lipoprotein (HDL) and low density lipoprotein (LDL) particle size distributions in samples from > 1100 participants in the San Antonio Family Heart Study. By use of analyses ofindividual correlations of each HDL fraction with each LDL fraction, we devised new metrics for particle size phenotype, termed Delta HDL and Delta LDL, to optimally reflect the size correlations. Confirming previous studies, we found that the 2 size phenotype variables were positively correlated (r = 0.51). Quantitative genetic analysis indicated that nearly half (44%) of the variance in Delta HDL and in Delta LDL was explained by the additive effects of genes. Bivariate genetic analyses indicated that a positive genetic correlation (rho (G) = 0.56) exists between them and suggested that thepleiotropic effects of a gene or group of genes account for approximate to31% [ie, rho (2)(G) = (0.56)(2) = 0.31] of the genetic variance in the 2 traits. Triglyceride (TG) levels were negatively related to Delta HDL and Delta LDL, with phenotypic correlations of -0.48 and -0.58, respectively, andgenetic correlations of -0.45 and -0.76, respectively, suggesting that genes exert significant pleiotropic effects on the covariation of TGs with each of the size variables. Finally, we evaluated a bivariate model for Delta HDL and Delta LDL in which TG level was included as a covariate. This analysis indicated that a small but significant genetic correlation remains for Delta HDL and Delta LDL, even after accounting for the effects of TGs. Thus, our study demonstrates that the phenotypic correlation of HDL and LDL sizes results in part from the pleiotropic actions of a set of genes, some of which also influence TG levels and some of which do not.

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Documento generato il 01/12/20 alle ore 08:23:51