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Titolo:
Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors
Autore:
Takemoto, M; Liao, JK;
Indirizzi:
Brigham & Womens Hosp, Dept Med, Div Cardiovasc, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 ardiovasc, Boston, MA 02115 USA Harvard Univ, Sch Med, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 vard Univ, Sch Med, Boston, MA 02115 USA
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 11, volume: 21, anno: 2001,
pagine: 1712 - 1719
SICI:
1079-5642(200111)21:11<1712:PEO3CA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; C-REACTIVE PROTEIN; VASCULAR SMOOTH-MUSCLE; CORONARY HEART-DISEASE; AVERAGE CHOLESTEROL LEVELS; CARDIOVASCULAR-DISEASE; ENDOTHELIAL-CELLS; PLAQUE RUPTURE; A REDUCTASE; ATHEROSCLEROTIC PLAQUES;
Keywords:
endothelium; vascular smooth muscle; platelets; atherosclerosis; inflammation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
120
Recensione:
Indirizzi per estratti:
Indirizzo: Liao, JK Brigham & Womens Hosp, Dept Med, Div Cardiovasc, 221 Longwood Ave,LMRC-322, Boston, MA 02115 USA Brigham & Womens Hosp 221 Longwood Ave,LMRC-322 Boston MA USA 02115
Citazione:
M. Takemoto e J.K. Liao, "Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors", ART THROM V, 21(11), 2001, pp. 1712-1719

Abstract

The 3-hydroxy-3-methylglutaryl coenzyme. A reductase inhibitors or statinsare potent inhibitors of cholesterol biosynthesis. Several large clinical trials have demonstrated the beneficial effects of statins in the primary and secondary prevention of coronary heart disease. However, the overall clinical benefits observed with statin therapy appear to be greater than what might be expected from changes in lipid profile alone, suggesting that the beneficial effects of statins may extend beyond their effects on serum cholesterol levels. Indeed, recent experimental and clinical evidence indicatesthat some of the cholesterol-independent or "pleiotropic" effects of statins involve improving or restoring endothelial function, enhancing the stability of atherosclerotic plaques, and decreasing oxidative stress and vascular inflammation. Many of these pleiotropic effects of statins are mediated by their ability to block the synthesis of important isoprenoid intermediates, which serve as lipid attachments for a variety of intracellular signaling molecules. In particular, the inhibition of small GTP-binding proteins, Rho, Ras, and Rac, whose proper membrane localization and function are dependent on isoprenylation, may play an important role in mediating the directcellular effects of statins on the vascular wall.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 04:12:20