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Titolo:
Hormone replacement therapy and lens opacities - The salisbury eye evaluation project
Autore:
Freeman, EE; Munoz, B; Schein, OD; West, SK;
Indirizzi:
Wilmer Eye Inst, Dana Ctr Prevent Ophthalmol, Baltimore, MD USA Wilmer EyeInst Baltimore MD USA r Prevent Ophthalmol, Baltimore, MD USA
Titolo Testata:
ARCHIVES OF OPHTHALMOLOGY
fascicolo: 11, volume: 119, anno: 2001,
pagine: 1687 - 1692
SICI:
0003-9950(200111)119:11<1687:HRTALO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
AGE-RELATED CATARACTS; BEAVER DAM EYE; ESTROGEN; POPULATION; PREVALENCE; RECEPTOR; CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: West, SK Johns Hopkins Univ Hosp, Wilmer Eye Inst, Rm 129,600 N Wolfe St, Baltimore, MD 21210 USA Johns Hopkins Univ Hosp Rm 129,600 N Wolfe St Baltimore MD USA 21210
Citazione:
E.E. Freeman et al., "Hormone replacement therapy and lens opacities - The salisbury eye evaluation project", ARCH OPHTH, 119(11), 2001, pp. 1687-1692

Abstract

Background: Data suggest a possible protective effect against lens opacitywith use of hormone replacement therapy (HRT). However, no agreement exists on which opacity type is affected, and more exploration of the additionalrole of endogenous estrogen exposure is warranted. Objective: To determine whether HRT and the prevalence of different lens opacity types are associated after controlling for endogenous estrogen exposure. Design and Setting: Salisbury Eye Evaluation population-based prevalence survey of residents in an eastern US city. Participants: One thousand two hundred thirty-nine women aged 65 through 84 years. Main Outcome Measures: Nuclear, cortical, and posterior subcapsular opacity. Results: We found a protective association between nuclear opacity and current (odds ratio [OR], 0.5; 95% confidence interval [CI], 0.3-0.7) and recent (OR, 0.4; 95% CI, 0.3-0.7) HRT use. Increasing number of births in younger women was also protective (test of trend, P=.05). Past HRT use protectedagainst nuclear opacity only in women who had never been pregnant (OR, 0.2; 95% CI, 0.1-0.7). Past (OR, 0.2; 95% CI, 0.1-0.7) and current (OR, 0.3; 95% CI, 0.1-0.9) HRT use were associated with a lower prevalence of posterior subcapsular opacity. Conclusion: A protective association between the use of HRT and nuclear and posterior subcapsular opacities is reported, which should be confirmed inprospective studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 21:01:23