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Titolo:
Subcellular steroid/nuclear receptor dynamics
Autore:
Kawata, M;
Indirizzi:
Kyoto Prefectural Univ Med, Dept Anat & Neurobiol, Kamigyo Ku, Kyoto 6028566, Japan Kyoto Prefectural Univ Med Kyoto Japan 6028566 Ku, Kyoto 6028566, Japan
Titolo Testata:
ARCHIVES OF HISTOLOGY AND CYTOLOGY
fascicolo: 4, volume: 64, anno: 2001,
pagine: 353 - 368
SICI:
0914-9465(200110)64:4<353:SSRD>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
GREEN FLUORESCENT PROTEIN; CENTRAL-NERVOUS-SYSTEM; LIVER GLUCOCORTICOID RECEPTOR; STEROID-HORMONE RECEPTOR; HUMAN ESTROGEN-RECEPTOR; LIVING CELLS; RAT-BRAIN; MONOCLONAL-ANTIBODIES; PROGESTERONE-RECEPTOR; NUCLEAR-LOCALIZATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
84
Recensione:
Indirizzi per estratti:
Indirizzo: Kawata, M Kyoto Prefectural Univ Med, Dept Anat & Neurobiol, Kamigyo Ku, Kyoto 6028566, Japan Kyoto Prefectural Univ Med Kyoto Japan 6028566 6028566, Japan
Citazione:
M. Kawata, "Subcellular steroid/nuclear receptor dynamics", ARCH HIST C, 64(4), 2001, pp. 353-368

Abstract

Steroid hormones, thyroid hormones, retinoic acids, and vitamin D bind to their receptors, which are now called steroid/nuclear receptors, and liganded receptors translocate either intracellularly or intranuclearly and form large protein complexes with cofactors to induce or repress gene transcription. Therefore, steroid/nuclear receptors are ligand-dependent transcription factors. With the advent of green fluorescent protein (GFP) and its color variants,the subcellular distribution of many steroid/nuclear receptors has been found to be much more dynamic than previously thought, with some of the receptors shuttling between the cytoplasm and nucleus. Steroid/nuclear receptorscan be divided into three categories based on their unliganded distribution: those that are primarily in the nucleus, those in the cytoplasm, and those with mixed cytoplasmic and nuclear distributions. However, in all cases,the addition of a ligand leads to almost complete nuclear translocation ofthe receptors. Hormonal stimulation induces intranuclear receptor distribution from a homogeneous pattern to a heterogeneous dot-like image. Ligand binding to steroid/nuclear receptors leads to the recruitment of many proteins including cofactors to provoke the redistribution of receptor complexes in the nucleus. This focal organization could involve more complex events than simple DNA binding sites for transcription. Protein activities and interactions of steroid/nuclear receptors can be imaged and localized in a single cell.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:38:56