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Titolo:
CpG motif identification for veterinary and laboratory species demonstrates that sequence recognition is highly conserved
Autore:
Rankin, R; Pontarollo, R; Ioannou, X; Krieg, AM; Hecker, R; Babiuk, LA; van Drunen, S; van den Hurk, LV;
Indirizzi:
Univ Saskatchewan, Vet Infect Dis Org, Saskatoon, SK 57N 5E3, Canada Univ Saskatchewan Saskatoon SK Canada 57N 5E3 skatoon, SK 57N 5E3, Canada Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA Univ Iowa Iowa CityIA USA 52242 pt Internal Med, Iowa City, IA 52242 USA Vet Affairs Med Ctr, Iowa City, IA 52242 USA Vet Affairs Med Ctr Iowa City IA USA 52242 d Ctr, Iowa City, IA 52242 USA Coley Pharmaceut Grp, Wellesley, MA 02481 USA Coley Pharmaceut Grp Wellesley MA USA 02481 Grp, Wellesley, MA 02481 USA Qiagen GMBH, Hilden, Germany Qiagen GMBH Hilden GermanyQiagen GMBH, Hilden, Germany
Titolo Testata:
ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT
fascicolo: 5, volume: 11, anno: 2001,
pagine: 333 - 340
SICI:
1087-2906(200110)11:5<333:CMIFVA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY SYNCYTIAL VIRUS; BACTERIAL-DNA; IMMUNE-RESPONSES; BOVINE HERPESVIRUS-1; B-CELLS; IN-VIVO; OLIGODEOXYNUCLEOTIDES; VACCINE; ADJUVANTS; MURINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: van den Hurk, LV Univ Saskatchewan, Vet Infect Dis Org, 120 Vet Rd, Saskatoon, SK 57N 5E3, Canada Univ Saskatchewan 120 Vet Rd Saskatoon SK Canada 57N 5E3
Citazione:
R. Rankin et al., "CpG motif identification for veterinary and laboratory species demonstrates that sequence recognition is highly conserved", ANTISENSE N, 11(5), 2001, pp. 333-340

Abstract

Oligodinucleotides containing CpG motifs stimulate vertebrate immune cellsin vitro, have proven efficacy in murine disease models and are currently being tested in human clinical trials as therapies for cancer, allergy, andinfectious disease. As there are no known immunostimulatory motifs for veterinary species, the potential of CpG DNA as a veterinary pharmaceutical has not been investigated. Here, optimal CpG motifs for seven veterinary and three laboratory species are described. The preferential recognition of a GTCGTT motif was strongly conserved across two vertebrate phyla, although a GACGTT motif was optimal for inbred strains of mice and rabbits. In a subsequent adjuvanticity trial, the in vitro screening methodology was validatedin sheep, representing the first demonstration of CpG DNA efficacy in a veterinary species. These results should provide candidate immunostimulant and therapeutic drugs for veterinary use and enable the testing of CpG DNA inlarge animal models of human disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 05:30:35